Methylpiperidinopyrazole (MPP) is a
synthetic,
nonsteroidal A nonsteroidal compound is a drug that is not a steroid nor a steroid derivative. Nonsteroidal anti-inflammatory drugs (NSAIDs) are distinguished from corticosteroids as a class of anti-inflammatory agents.
List of nonsteroidal steroid receptor mo ...
, and highly selective
antagonist of
ERα
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as a chromatin-binding protein)
that is activated by the sex h ...
that is used in
scientific research
The scientific method is an empirical method for acquiring knowledge that has characterized the development of science since at least the 17th century (with notable practitioners in previous centuries; see the article history of scientific m ...
to study the function of this
receptor.
It has 200-fold selectivity for ERα over
ERβ and 1000-fold selectivity for blocking ERα-mediated gene transcription relative to that of ERβ.
See also
*
Glyceollin
Glyceollins are a family of prenylated pterocarpans found in ineffective types of nodule in soybean in response to symbiotic infection.
It possesses two chiral centers and can be asymmetrically synthesized chemically at a gram level scale.
Mol ...
*
Propylpyrazoletriol
Propylpyrazoletriol (PPT) is a synthetic, nonsteroidal agonist of ERα with 400-fold selectivity over ERβ that is used widely in scientific research to study the function of ERα. Though originally thought to be highly selective for ERα, P ...
(PPT)
*
Diarylpropionitrile (DPN)
*
Prinaberel (ERB-041)
*
Liquiritigenin
*
Menerba
*
PHTPP
*
(R,R)-Tetrahydrochrysene ((R,R)-THC)
References
Antiestrogens
1-Piperidinyl compounds
Phenol ethers
Phenols
Pyrazoles
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