In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, a methylmalonate-semialdehyde dehydrogenase (acylating) () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:2-methyl-3-oxopropanoate + CoA + H
2O + NAD
+ propanoyl-CoA + HCO
3- + NADH
The 4
substrates of this enzyme are
2-methyl-3-oxopropanoate,
CoA,
H2O, and
NAD+, whereas its 3
products are
propanoyl-CoA,
HCO3-, and
NADH.
This enzyme belongs to the family of
oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The
systematic name of this enzyme class is 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating). Other names in common use include MSDH, and MMSA dehydrogenase. This enzyme participates in 3
metabolic pathways:
inositol metabolism,
valine, leucine and isoleucine degradation, and
propanoate metabolism.
Structural studies
As of late 2007, only one
structure
A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects such as ...
has been solved for this class of enzymes, with the
PDB accession code .
References
*
*
*
EC 1.2.1
NADH-dependent enzymes
Enzymes of known structure
{{1.2-enzyme-stub