Metaclazepam (marketed under the brand name Talis) is a drug which is a benzodiazepine derivative. It is a relatively selective

anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...

with less sedative or

muscle relaxant A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therap ...

properties than other benzodiazepines such as

diazepam Diazepam, first marketed as Valium, is a medicine of the benzodiazepine family that acts as an anxiolytic. It is commonly used to treat a range of conditions, including anxiety, seizures, alcohol withdrawal syndrome, muscle spasms, insomnia, ...

or bromazepam. It has an

active metabolite An active metabolite is an active form of a drug after it has been processed by the body. Metabolites of drugs An active metabolite results when a drug is metabolized by the body into a modified form which continues to produce effects in the body ...

''N''-desmethylmetaclazepam, which is the main metabolite of metaclazepam. There is no significant difference in metabolism between younger and older individuals. Metaclazepam is slightly more effective as an anxiolytic than bromazepam, or

, with a 15 mg dose of metaclazepam equivalent to 4 mg of bromazepam. Metaclazepam can interact with alcohol producing additive sedative-hypnotic effects. Fatigue is a common side effect from metaclazepam at high doses. Small amounts of metaclazepam as well as its metabolites enter into human breast milk.

References

{{GABAAR PAMs Benzodiazepines Chloroarenes Ethers GABAA receptor positive allosteric modulators Organobromides

See also

References