Melatonin receptor 1A

Melatonin receptor type 1A is a protein that in humans is encoded by the ''MTNR1A'' gene.

Function

This gene encodes the MT₁ protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the pituitary gland, hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

Ligands

# Melatonin – full agonist
# Afobazole – agonist
# Agomelatine – agonist

See also

* Melatonin receptor
* Discovery and development of melatonin receptor agonists

References

Further reading

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G protein-coupled receptors
Human proteins
Melatonin, 1A

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