Melanin-concentrating hormone receptor 1, also known as MCH
1, is one of the
melanin-concentrating hormone receptors found in all mammals.
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds
melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to
somatostatin receptor
Somatostatin receptors are receptors for the ligand somatostatin, a small neuropeptide associated with neural signaling, particularly in the post-synaptic response to NMDA receptor co-stimulation/activation. Somatostatin is encoded by a CRE ...
s, this protein does not seem to bind
somatostatin.
Function
MCH
1 is thought to have a number of functions including in the regulation of appetite,
and in stress, anxiety and depression.
Selective ligands
Agonists
*
Melanin concentrating hormone
Melanin-concentrating hormone (MCH), also known as pro-melanin stimulating hormone (PMCH), is a cyclic 19-amino acid orexigenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish, where it controls skin pigmentation ...
(MCH)
* S-36057 - modified MCH 6-13 fragment substituted with 3-iodotyrosine at N-terminus via dioxyoctanoyl linker, used as
125I
radioligand
A radioligand is a radioactive biochemical substance (in particular, a ligand (biochemistry), ligand that is radioactive tracer, radiolabeled) that is used for diagnosis or for research-oriented study of the receptor (biochemistry), receptor system ...
for mapping MCH
1 ''in vivo''.
*
LK-184 (
Procter & Gamble
The Procter & Gamble Company (P&G) is an American multinational consumer goods corporation headquartered in Cincinnati, Ohio, founded in 1837 by William Procter and James Gamble. It specializes in a wide range of personal health/consumer he ...
) is one pick
Antagonists
* ATC-0065
*
ATC-0175
*
GW-803,430
*
NGD-4715
*
SNAP-7941
*
SNAP-94847
* T-226,296
See also
*
Melanin-concentrating hormone receptor
References
Further reading
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External links
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{{G protein-coupled receptors
G protein-coupled receptors
Human proteins