Max Tishler (October 30, 1906 – March 18, 1989) was president of

Merck Sharp and Dohme Research Laboratories Merck & Co., Inc. is an American multinational pharmaceutical company headquartered in Rahway, New Jersey, and is named for Merck Group, founded in Germany in 1668, of whom it was once the American arm. The company does business as Merck Sharp ...

where he led the research teams that synthesized

ascorbic acid Vitamin C (also known as ascorbic acid and ascorbate) is a water-soluble vitamin found in citrus and other fruits and vegetables, also sold as a dietary supplement and as a topical 'serum' ingredient to treat melasma (dark pigment spots) an ...

riboflavin Riboflavin, also known as vitamin B2, is a vitamin found in food and sold as a dietary supplement. It is essential to the formation of two major coenzymes, flavin mononucleotide and flavin adenine dinucleotide. These coenzymes are involved in ...

cortisone Cortisone is a pregnene (21-carbon) steroid hormone. It is a naturally-occurring corticosteroid metabolite that is also used as a pharmaceutical prodrug; it is not synthesized in the adrenal glands. Cortisol is converted by the action of the enzy ...

pyridoxine Pyridoxine, is a form of vitamin B6 found commonly in food and used as a dietary supplement. As a supplement it is used to treat and prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorde ...

pantothenic acid Pantothenic acid, also called vitamin B5 is a water-soluble B vitamin and therefore an essential nutrient. All animals require pantothenic acid in order to synthesize coenzyme A (CoA) – essential for fatty acid metabolism – as well as to, i ...

nicotinamide Niacinamide or Nicotinamide (NAM) is a form of vitamin B3 found in food and used as a dietary supplement and medication. As a supplement, it is used by mouth to prevent and treat pellagra (niacin deficiency). While nicotinic acid (niacin) may ...

methionine Methionine (symbol Met or M) () is an essential amino acid in humans. As the precursor of other amino acids such as cysteine and taurine, versatile compounds such as SAM-e, and the important antioxidant glutathione, methionine plays a critical ro ...

threonine Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH form under biological conditions), a carboxyl group (which is in the deprotonated −COO� ...

, and

tryptophan Tryptophan (symbol Trp or W) is an α-amino acid that is used in the biosynthesis of proteins. Tryptophan contains an α-amino group, an α- carboxylic acid group, and a side chain indole, making it a polar molecule with a non-polar aromatic ...

. He also developed the

fermentation Fermentation is a metabolic process that produces chemical changes in organic substrates through the action of enzymes. In biochemistry, it is narrowly defined as the extraction of energy from carbohydrates in the absence of oxygen. In food ...

processes for

actinomycin Dactinomycin, also known as actinomycin D, is a chemotherapy medication used to treat a number of types of cancer. This includes Wilms tumor, rhabdomyosarcoma, Ewing's sarcoma, trophoblastic neoplasm, testicular cancer, and certain types of ovari ...

, vitamin B₁₂,

streptomycin Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including tuberculosis, ''Mycobacterium avium'' complex, endocarditis, brucellosis, ''Burkholderia'' infection, plague, tularemia, and rat bite fever. Fo ...

, and

penicillin Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from ''Penicillium'' moulds, principally '' P. chrysogenum'' and '' P. rubens''. Most penicillins in clinical use are synthesised by P. chrysogenum using ...

. Tishler invented sulfaquinoxaline for the treatment for

coccidiosis Coccidiosis is a parasitic disease of the intestinal tract of animals caused by coccidian protozoa. The disease spreads from one animal to another by contact with infected feces or ingestion of infected tissue. Diarrhea, which may become bloody in ...

Biography

He was born in Boston, Massachusetts on October 30, 1906. His father repaired shoes and he abandoned the family in 1911. Max worked in a pharmacy during the

flu pandemic of 1918 The 1918–1920 influenza pandemic, commonly known by the misnomer Spanish flu or as the Great Influenza epidemic, was an exceptionally deadly global influenza pandemic caused by the H1N1 influenza A virus. The earliest documented case was ...

. He studied chemistry as an undergraduate at

Tufts College Tufts University is a private research university on the border of Medford and Somerville, Massachusetts. It was founded in 1852 as Tufts College by Christian universalists who sought to provide a nonsectarian institution of higher learning. ...

, where he was a member of the

Pi Lambda Phi Pi Lambda Phi (), commonly known as Pi Lam, is a social fraternity with 145 chapters (44 active chapters/colonies). The fraternity was founded in 1895 at Yale University in New Haven, Connecticut. Pi Lambda Phi is headlined by prestigious chapte ...

fraternity A fraternity (from Latin language, Latin ''wiktionary:frater, frater'': "brother (Christian), brother"; whence, "wiktionary:brotherhood, brotherhood") or fraternal organization is an organization, society, club (organization), club or fraternal ...

. In 1934 he earned his

Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is ...

organic chemistry Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; ...

from

Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...

. He married Elizabeth M. Verveer in 1934. He taught at Harvard from 1934 to 1937. His son, Peter Verveer Tishler, was born on July 18, 1937. In 1937, he took a position at Merck. His first project at Merck was to produce

. In the 1940s he developed a process for the synthesis of

. In 1970 he retired from Merck, and taught chemistry at

Wesleyan University Wesleyan University ( ) is a Private university, private liberal arts college, liberal arts university in Middletown, Connecticut. Founded in 1831 as a Men's colleges in the United States, men's college under the auspices of the Methodist Epis ...

. He died of

emphysema Emphysema, or pulmonary emphysema, is a lower respiratory tract disease, characterised by air-filled spaces ( pneumatoses) in the lungs, that can vary in size and may be very large. The spaces are caused by the breakdown of the walls of the alve ...

at Middlesex Memorial Hospital in

Middletown, Connecticut Middletown is a city located in Middlesex County, Connecticut, United States, Located along the Connecticut River, in the central part of the state, it is south of Hartford, Connecticut, Hartford. In 1650, it was incorporated by English settler ...

on March 18, 1989.

Education

*B.S. Chemistry,

, 1928, magna cum laude *M.A. Chemistry,

, 1933 *Ph.D. Organic Chemistry,

, 1934 :Research Advisor: Elmer P. Kohler, Dissertation title: "I. The reduction of alpha halo-ketones. II. The action of organic magnesium halides on alpha halo-ketones and on alpha halo-sulfones."

Honors

Chemical Pioneer Award The Chemical Pioneer Award, established in 1966, is awarded by the American Institute of Chemists to recognize chemists or chemical engineers who have made outstanding contributions to advances in chemistry or the chemical profession. Recent rec ...

(1968) *

Priestley Medal The Priestley Medal is the highest honor conferred by the American Chemical Society (ACS) and is awarded for distinguished service in the field of chemistry. Established in 1922, the award is named after Joseph Priestley, the discoverer of oxygen ...

(1970) *

American Institute of Chemists Gold Medal The American Institute of Chemists Gold Medal is the highest award of the American Institute of Chemists and has been awarded since 1926. It is presented annually to a person who has most encouraged the science of chemistry or the profession of ...

(1977) *

National Medal of Science The National Medal of Science is an honor bestowed by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral and social scienc ...

National Inventors Hall of Fame The National Inventors Hall of Fame (NIHF) is an American not-for-profit organization, founded in 1973, which recognizes individual engineers and inventors who hold a U.S. patent of significant technology. Besides the Hall of Fame, it also opera ...

IRI Medal The IRI Medal, established by the Industrial Research Institute (IRI) in 1946, recognizes and honors leaders of technology for their outstanding accomplishments in technological innovation which contribute broadly to the development of industry and ...

References

Wesleyan University faculty 20th-century American chemists National Medal of Science laureates Harvard University alumni 1906 births 1989 deaths People from Boston Tufts University alumni 20th-century American inventors {{US-chemist-stub