Mark A. Lemmon
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Mark Andrew Lemmon (born 1964) an English-born biochemist, is the Alfred Gilman Professor and Department Chair of
Pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
at Yale University where he also directs the Cancer Biology Institute.


Education

Lemmon was born in Norfolk, England in 1964 and grew up in Taverham and Poringland. He was educated at Norwich School (from 1976 to 1983), and then at Hertford College, Oxford, from which he graduated with a first class Bachelor of Arts (BA) degree in biochemistry in 1988. He completed his PhD at Yale University as a
Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...
Predoctoral Fellow supervised by
Donald Engelman Donald Max Engelman (born 1941) is Higgins Professor of Biochemistry at Yale University. He is a member of the National Academy of Sciences (1997), fellow of the American Academy of Arts and Sciences, a fellow of the National Institutes of Healt ...
for research on the
oligomer In chemistry and biochemistry, an oligomer () is a molecule that consists of a few repeating units which could be derived, actually or conceptually, from smaller molecules, monomers.Quote: ''Oligomer molecule: A molecule of intermediate relativ ...
ization of transmembrane α-helices.


Research and career

Following his PhD, Lemmon was a postdoctoral researcher and fellow of the
Damon Runyon Cancer Research Foundation The Damon Runyon Cancer Research Foundation (Damon Runyon) is an American not-for-profit cancer research organization focused on "discovering the talent to discover the cure". The organization states that its goals are to: "identify the best an ...
at New York University in the laboratory of
Joseph Schlessinger Joseph Schlessinger (born Josip Schlessinger; 26 March 1945) is a Yugoslav-born Israeli- American biochemist and biophysician. He is chair of the Pharmacology Department at Yale University School of Medicine in New Haven, Connecticut, as wel ...
. Following his postdoctoral research, Lemmon was recruited to the department of biochemistry and biophysics at the University of Pennsylvania Perelman School of Medicine, where he gained tenure in 2001 and became departmental chair in 2008 before moving to Yale University in 2015. Lemmon's research combines biochemistry and structural biology with
cell biology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and ...
, focusing on understanding molecular mechanisms of transmembrane signalling by cell-surface growth factor receptors such as the epidermal growth factor (EGF) receptor and other receptor tyrosine kinases. With Kathryn Ferguson and others, he also played an important role in understanding the structure and function of the Pleckstrin homology domain in phosphoinositide signalling and elsewhere. Lemmon has made important contributions to the discovery of both normal and pathological activation mechanisms of growth factor receptors and the signalling networks that they engage within cells. He is also committed to exploiting this understanding clinically. These receptors and their downstream effectors are activated aberrantly in numerous cancers, and are important targets of cancer drugs. Lemmon's recent work has focused on the need to understand the biochemistry of oncogenic activation to use such drugs effectively. Before moving to Yale, Lemmon was George W. Raiziss Professor and Chair of Biochemistry and Biophysics in the
Perelman School of Medicine at the University of Pennsylvania The Perelman School of Medicine, commonly known as Penn Med, is the medical school of the University of Pennsylvania, a private research university in Philadelphia, Pennsylvania. Founded in 1765, the Perelman School of Medicine is the oldest medi ...
. His research has been funded by the National Cancer Institute, the National Institute of General Medical Sciences, and the Department of Defense Congressionally Directed Medical Research Programs.Mark Lemmon's Lemmon serves on the editorial boards of several scientific journals, including '' Cell'', '' Molecular Cell'', '' Molecular and Cellular Biology'', and ''
Science Signaling ''Science Signaling'' is a Peer review, peer-reviewed scientific journal that is focused on cell signaling and regulation. It is published weekly by the American Association for the Advancement of Science (AAAS). The editor-in-chief (Chief Scientif ...
''. Having served as an associate editor for the '' Biochemical Journal'' for many years, he was appointed chair of the editorial board in January 2021. Between 2007 and 2013, Lemmon served as secretary for the American Society for Biochemistry and Molecular Biology (ASBMB).


Awards and honours

Lemmon was elected a Fellow of the Royal Society (FRS) in 2016, One or more of the preceding sentences incorporates text from the royalsociety.org website where: as an ASBMB Fellow in 2023, and as a Member of the Connecticut Academy of Science and Engineering (CASE) in 2024. In 2012 Lemmon was awarded the
Dorothy Hodgkin Dorothy Mary Crowfoot Hodgkin (née Crowfoot; 12 May 1910 – 29 July 1994) was a Nobel Prize-winning British chemist who advanced the technique of X-ray crystallography to determine the structure of biomolecules, which became essential fo ...
prize by the Protein Society.


References

{{DEFAULTSORT:Lemmon, Mark Andrew Living people Fellows of the Royal Society People educated at Norwich School Alumni of Hertford College, Oxford British biochemists American biochemists 1964 births People from Broadland (district) People from South Norfolk (district)