Mario Trejo may refer to:
*
Mario Trejo (writer), Argentine poet, playwright, screenwriter, and journalist
*
Mario Trejo (footballer, born 1956), Mexican football manager and former defender
*
Mario Trejo (footballer, born 1971), Mexican football manager and former defender
*
Mario Trejo (footballer, born 1999), Mexican football defender
{{hndis, Trejo, Mario