Mario Romero may refer to:
* Mario Romero (poet) (1943–1998), Argentine poet, playwright and translator
* Mario Romero (Nicaraguan boxer), Nicaraguan Olympic boxer
* Mario Romero (Venezuelan boxer), Venezuelan Olympic boxer
* Mario Antonio Romero (born 1980), Argentine football striker
* Mario Luna Romero, tribal secretary of the Yaqui tribe of Vicam, Sonora
{{hndis, Romero, Mario