Mannosidase is an enzyme which hydrolyses
mannose
Mannose is a sugar monomer of the aldohexose series of carbohydrates. It is a C-2 epimer of glucose. Mannose is important in human metabolism, especially in the glycosylation of certain proteins. Several congenital disorders of glycosylat ...
.
There are two types:
*
alpha-Mannosidase
alpha-Mannosidase (, ''alpha-D-mannosidase'', ''p-nitrophenyl-alpha-mannosidase'', ''alpha-D-mannopyranosidase'', ''1,2-alpha-mannosidase'', ''1,2-alpha-D-mannosidase'', ''exo-alpha-mannosidase'') is an enzyme involved in the cleavage of the a ...
*
beta-Mannosidase
Beta-mannosidase (, ''mannanase'', ''mannase'', ''beta-D-mannosidase'', ''beta-mannoside mannohydrolase'', ''exo-beta-D-mannanase'', ''lysosomal beta A mannosidase'') is an enzyme with systematic name ''beta-D-mannoside mannohydrolase'', which ...
A deficiency is associated with
mannosidosis Mannosidosis is a deficiency in mannosidase, an enzyme.
There are two types:
* Alpha-mannosidosis
* Beta-mannosidosis
See also
*Swainsonine
Swainsonine is an indolizidine alkaloid. It is a potent inhibitor of Golgi alpha-mannosidase II, an ...
.
A family of mannosidases are also responsible for processing newly formed glycoproteins in the endoplasmic reticulum into mature glycoproteins containing highly heterogeneous complex-type glycans.
References
EC 3.2.1
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