RefSeq (protein)



Location (UCSC) Chr 7: 15.61 – 15.69 Mb Chr 12: 37.11 – 37.18 Mb PubMed search [3] [4] Wikidata
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Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.[5][6]


This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[6]


MEOX2 has been shown to interact with PAX1[7] and PAX3.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106511 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036144 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ LePage DF, Altomare DA, Testa JR, Walsh K (May 1995). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics. 24 (3): 535–40. doi:10.1006/geno.1994.1663. PMID 7713505. 
  6. ^ a b "Entrez Gene: MEOX2 mesenchyme homeobox 2". 
  7. ^ a b Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.