MyoD family inhibitor is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''MDFI''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.
Interactions
MDFI has been shown to
interact
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with:
*
C9orf86,
*
GNAI2
Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the ''GNAI2'' gene.
Interactions
GNAI2 has been shown to interact with:
* EYA2,
* GPSM2,
* Interleukin 8 receptor, alpha,
* MDFI,
* RGS5, ...
,
[
* ]MyoD
MyoD, also known as myoblast determination protein 1, is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, belongs to a family of proteins kno ...
,Myogenin
Myogenin, is a transcriptional activator encoded by the MYOG gene.
Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is ...
,[ and
* ]SIX1
Homeobox protein SIX1 (Sine oculis homeobox homolog 1) is a protein that in humans is encoded by the ''SIX1'' gene.
Function
The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the ...
.[
]
References
Further reading
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