The MAS1 oncogene (MAS receptor) is a
G protein-coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
which binds the
angiotensin II metabolite
angiotensin (1-7)
Angiotensin (1-7) (; Molecular weight = 899.02 g/mol; H- Asp- Arg-Val- Tyr- Ile-His- Pro-OH) is an active heptapeptide of the renin–angiotensin system (RAS).
In 1988, Santos ''et al'' demonstrated that angiotensin (1-7) was a main product of th ...
.
The MAS1 receptor, when activated by binding angiotensin-(1-7), opposes many of the effects of the
angiotensin II receptor. Hence, MAS1 receptor
agonists have similar therapeutic effects to
angiotensin II receptor antagonists
Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT1) antagonists, also known as angiotensin receptor blockers, angiotensin II receptor antagonists, or AT1 receptor antagonists, are a group of pharmaceuticals tha ...
, including lowering of blood pressure.
References
External links
IUPHAR GPCR Database - MAS1IUPHAR GPCR Database - MAS1L*
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