M66 may refer to:
*
M66 (New York City bus)
Several companies, most prominently the Metropolitan Transportation Authority (MTA), operate a number of bus routes in Manhattan, New York, United States. Many of them are the direct descendants of streetcar lines (see list of streetcar lines in ...
, a New York City Bus route in Manhattan
*
M-66 (Michigan highway), a state highway in Michigan
*
M66 motorway, a motorway in Greater Manchester, England
*
Black Magic M66
is a cyberpunk manga written and illustrated by Masamune Shirow. It was first published as a ''dōjinshi'' in 1983, and was later reprinted in ''tankōbon'' format by Seishinsha in 1985. The series was later adapted into an OVA in 1987 whi ...
, the classification of a fictional android
*
Messier 66
Messier 66 or M66, also known as NGC 3627, is an intermediate spiral galaxy in the southern, equatorial half of Leo. It was discovered by French astronomer Charles Messier on 1 March 1780, who described it as "very long and very faint". This g ...
, a spiral galaxy in the constellation Leo
*
Soltam M-66
The M-66 is a 160 mm mortar manufactured by Soltam of Israel. The weapon was based on an earlier 160 mm design, the M-58 mortar by Vammas of Finland. It can fire a 38 kg (84 lb) HE bomb out to a maximum range of 9,600 m and re ...
, a 160 mm mortar manufactured in Israel
* Smith & Wesson Model 66 (S&W M66), a variant of
Smith & Wesson Model 19 (S&W M19) revolver
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