Müller's sign is the pulsation or bobbing of the

uvula The palatine uvula, usually referred to as simply the uvula, is a conic projection from the back edge of the middle of the soft palate, composed of connective tissue containing a number of racemose glands, and some muscular fibers. It also conta ...

that occurs during systole. It can be seen in patients with severe

aortic insufficiency Aortic regurgitation (AR), also known as aortic insufficiency (AI), is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle. As a conseq ...

. Müller's sign is caused by an increased stroke volume. Müller's sign is named for

Friedrich von Müller Friedrich von Müller (17 September 1858, Augsburg – 18 November 1941, Munich) was a German physician remembered for describing Müller's sign. He was the son of the head of the medical department in the hospital in Augsburg. He studied na ...

, a German physician.

References

Symptoms and signs: Cardiac {{med-sign-stub