Lupus miliaris disseminatus faciei, also known as acne agminata, is a disease with a similar appearance to
acne vulgaris.
[Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). Page 676. McGraw-Hill. .] The cause of LMDF is unknown.
LMDF usually occurs on the face, but extrafacial presentations have been reported.
Mycobacterium tuberculosis or its products may cause a caseous
necrosis and thus maybe one of several possible causes. Some authors view LMDF as a variant of granulomatous
rosacea
Rosacea is a long-term skin condition that typically affects the face. It results in redness, pimples, swelling, and small and superficial dilated blood vessels. Often, the nose, cheeks, forehead, and chin are most involved. A red, enlarg ...
or a presentation related to
Demodex
''Demodex'' is a genus of tiny mites that live in or near hair follicles of mammals. Around 65 species of ''Demodex'' are known. Two species live on humans: '' Demodex folliculorum'' and '' Demodex brevis'', both frequently referred to as eyela ...
folliculitis
Folliculitis is the infection and inflammation of one or more hair follicles. The condition may occur anywhere on hair-covered skin. The rash may appear as pimples that come to white tips on the face, chest, back, arms, legs, buttocks, or head.
...
. Others suggest it as a new independent entity and proposed a new term: Facial Idiopathic GranUlomas with Regressive Evolution. Misago et al. postulated LMDF as a common adult form,
childhood granulomatous periorificial dermatitis as a rare childhood form, and
perioral dermatitis
Perioral dermatitis, also known as periorificial dermatitis, is a common type of skin rash. Symptoms include multiple small (1–2 mm) bumps and blisters sometimes with background redness and scale, localized to the skin around the mouth and ...
as a peculiar form exacerbated by topical
corticosteroids. There are no
randomized controlled trial
A randomized controlled trial (or randomized control trial; RCT) is a form of scientific experiment used to control factors not under direct experimental control. Examples of RCTs are clinical trials that compare the effects of drugs, surgical te ...
s available for the treatment of LMDF.
The usual first-line therapy is oral
tetracyclines with variable success rates.
Dapsone, low-dose
prednisolone
Prednisolone is a steroid medication used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers. Some of these conditions include adrenocortical insufficiency, high blood calcium, rheumatoid arthr ...
,
clofazimine
Clofazimine, sold under the brand name Lamprene, is a medication used together with rifampicin and dapsone to treat leprosy. It is specifically used for multibacillary (MB) leprosy and erythema nodosum leprosum. Evidence is insufficient to sup ...
, and
isotretinoin
Isotretinoin, also known as 13-''cis''-retinoic acid and sold under the brand name Accutane among others, is a medication primarily used to treat severe acne. It is also used to prevent certain skin cancers ( squamous-cell carcinoma), and in t ...
have all been tried in some cases. The 1450-nm diode laser has been shown to improve LMDF.
Wang SH, Tsai TF (2007). "Several Erythematous Papules with a 1.5-cm Sized Nodule Scattering on the Face of an Old Woman". Dermatol Sinica. 25 (2): 175-6.
/ref>
See also
* List of cutaneous conditions
References
External links
Acneiform eruptions
{{Cutaneous-condition-stub