Lithium citrate (Li₃C₆H₅O₇) is a chemical compound of

lithium Lithium (from el, λίθος, lithos, lit=stone) is a chemical element with the symbol Li and atomic number 3. It is a soft, silvery-white alkali metal. Under standard conditions, it is the least dense metal and the least dense solid ...

and

citrate Citric acid is an organic compound with the chemical formula HOC(CO2H)(CH2CO2H)2. It is a colorless weak organic acid. It occurs naturally in citrus fruits. In biochemistry, it is an intermediate in the citric acid cycle, which occurs in the ...

that is used as a mood stabilizer in psychiatric treatment of manic states and

bipolar disorder Bipolar disorder, previously known as manic depression, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood that last from days to weeks each. If the elevated mood is severe or associated with ...

. There is extensive pharmacology of lithium, the active component of this salt.

Lithia water Lithia water is defined as a type of mineral water characterized by the presence of lithium salts (such as the carbonate, chloride, or citrate of lithium). Natural lithia mineral spring waters are rare, and there are few commercially bottled lith ...

contains various lithium salts, including the citrate.

History

An early version of

Coca-Cola Coca-Cola, or Coke, is a carbonated soft drink manufactured by the Coca-Cola Company. Originally marketed as a temperance drink and intended as a patent medicine, it was invented in the late 19th century by John Stith Pemberton in Atlant ...

available in pharmacies' soda fountains called Lithia Coke was a mixture of Coca-Cola syrup and

lithia water Lithia water is defined as a type of mineral water characterized by the presence of lithium salts (such as the carbonate, chloride, or citrate of lithium). Natural lithia mineral spring waters are rare, and there are few commercially bottled lith ...

. The soft drink

7Up 7 Up (stylized as 7up outside North America) is an American brand of lemon-lime-flavored non-caffeinated soft drink. The brand and formula are owned by Keurig Dr Pepper although the beverage is internationally distributed by PepsiCo. 7 Up co ...

was originally named "Bib-Label Lithiated Lemon-Lime Soda" when it was formulated in 1929 because it contained lithium citrate. The beverage was a

patent medicine A patent medicine, sometimes called a proprietary medicine, is an over-the-counter (nonprescription) medicine or medicinal preparation that is typically protected and advertised by a trademark and trade name (and sometimes a patent) and claimed ...

marketed as a cure for

hangover A hangover is the experience of various unpleasant physiological and psychological effects usually following the consumption of alcohol, such as wine, beer, and liquor. Hangovers can last for several hours or for more than 24 hours. Typical sympto ...

. Lithium citrate was removed from 7Up in 1948 after it was banned by the

Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respon ...

. Lithium Citrate is used as a mood stabilizer and is used to treat mania,

hypomania Hypomania (literally "under mania" or "less than mania") is a mental and behavioural disorder, characterised essentially by an apparently non-contextual elevation of mood ( euphoria) that contributes to persistently disinhibited behaviour. Th ...

, depression and

. It can be administered orally in the form of a syrup.

References

Citrates Lithium salts Mood stabilizers Organolithium compounds {{nervous-system-drug-stub