This is a list of investigational

sexual dysfunction Sexual dysfunction is difficulty experienced by an individual or partners during any stage of normal sexual activity, including physical pleasure, desire, preference, arousal, or orgasm. The World Health Organization defines sexual dysfunction as ...

drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via insuffla ...

s, or drugs that are currently under development for clinical treatment of sexual dysfunction but are not yet approved. ''Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.''

Atrophic vaginitis

Estetrol Estetrol (E4), or oestetrol, is one of the four natural estrogenic steroid hormones found in humans, along with estrone (E1), estradiol (E2), and estriol (E3), estetrol is a major estrogen in the body. In contrast to estrone and estradiol, estet ...

(E4; Donesta) –

estrogen receptor Estrogen receptors (ERs) are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen ( 17β-estradiol). Two classes of ER exist: nuclear estrogen receptors (ERα and ERβ), which are members of the ...

agonis
Estetrol - Mithra Pharmaceuticals - AdisInsight
* Lasofoxifene (CP-336156, CP-336156-CB, Fablyn, Oporia) – selective estrogen receptor modulator
Lasofoxifene - Sermonix Pharmaceuticals - AdisInsight

Erectile dysfunction

* HCP-1302 – undefined mechanism of action
HCP 1302 - AdisInsight
* [ itroglycerin gel (Eroxon, Futura, MED-2001–MED-2005) – NO donor, nitric oxide donor
Nitroglycerin gel - Futura Medical - AdisInsight
* Tadalafil/tamsulosin (HCP-1303, CKD-397, YBH-160
Tadalafil/tamsulosin - Hanmi Pharmaceutical - AdisInsight
http://adisinsight.springer.com/drugs/800047508 Tadalafil/tamsulosin - Ildong Pharmaceutical - AdisInsigh
Tadalafil/tamsulosin - Chong Kun Dang - AdisInsight
http://adisinsight.springer.com/drugs/800044412 Tadalafil/tamsulosin - Yungjin Pharmaceutical - AdisInsight] * TT-701 (LY-2452473) –

OPK_88004_-_AdisInsight

_Female_anorgasmia

*_Testosterone_(medication).html" "title="selective androgen receptor modulator
OPK 88004 - AdisInsight

Female anorgasmia

* Testosterone (medication)">Testosterone Testosterone is the primary sex hormone and anabolic steroid in males. In humans, testosterone plays a key role in the development of Male reproductive system, male reproductive tissues such as testes and prostate, as well as promoting secondar ...

low-dose intranasal (MPP-14, TBS-2, Noseafix, Tefina) – androgen receptor agonis
Testosterone intranasal (low-dose) - Acerus Pharmaceuticals - AdisInsight

Female sexual dysfunction

* BP-101 – undefined mechanism of actio
BP 101 - Ovoca Bio - AdisInsight
* Bupropion/trazodone (S1P-104, S1P-205, Lorexys, Orexa) –

norepinephrine reuptake inhibitor A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epineph ...

nicotinic acetylcholine receptor Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral ne ...

antagonist An antagonist is a character in a story who is presented as the chief foe of the protagonist. Etymology The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, riv ...

, 5-HT_2A receptor antagonist, α₁-adrenergic receptor antagonist, weak serotonin reuptake inhibitor
Bupropion/trazodone - AdisInsight
* Buspirone/testosterone (Lybridos) – 5-HT1A receptor, 5-HT_1A receptor partial agonist and androgen receptor agonis
Buspirone/testosterone - Emotional Brain - AdisInsight
* Lasofoxifene (CP-336156, CP-336156-CB, Fablyn, Oporia) – selective estrogen receptor modulato
Lasofoxifene - Sermonix Pharmaceuticals - AdisInsight
*

PL-6983 PL-6983 is a synthetic peptide and selective MC4 receptor agonist which is under development by Palatin Technologies for the treatment of female sexual dysfunction and erectile dysfunction. It was developed as a successor to/replacement of brem ...

– selective MC₄ receptor agonis
Research programme: sexual dysfunction therapy - Palatin Technologies - AdisInsight
* Sildenafil/testosterone (Lybrido) –

PDE5 Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme () from the phosphodiesterase class. It is found in various tissues, most prominently the corpus cavernosum and the retina. It has also been recently discovered to p ...

inhibitor Inhibitor or inhibition may refer to: In biology * Enzyme inhibitor, a substance that binds to an enzyme and decreases the enzyme's activity * Reuptake inhibitor, a substance that increases neurotransmission by blocking the reuptake of a neurotra ...

and androgen receptor agonis
Sildenafil/testosterone - Emotional Brain - AdisInsight
* TGFK09SD – 5-HT_1A receptor agonis
TGFK 09SD - AdisInsight

Premature ejaculation

* Clomipramine/sildenafil (CDFR-0812) – serotonin reuptake inhibitor and PDE5 inhibito
Clomipramine/sildenafil - CTC Bio - AdisInsight
* DA-8031 – serotonin reuptake inhibito
DA 8031 - AdisInsight
* IX-01 – oxytocin receptor antagonis
Cligosiban - Ixchelsis - AdisInsight
* OnabotulinumtoxinA (botulinum toxin A, Botox) –

acetylcholine Acetylcholine (ACh) is an organic chemical that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Part ...

release inhibitor
Onabotulinum toxin A - AbbVie - AdisInsight

Unspecified

* Vilazodone (Viibryd, EMD-68843, SB-659746A) – 5-HT_1A receptor partial agonist and serotonin reuptake inhibito
Vilazodone - AbbVie - AdisInsight

References

External links

AdisInsight - Springer
{{Drugs for erectile dysfunction and premature ejaculation Sexual dysfunction drugs, investigational Experimental drugs Sexual dysfunction drugs