This list of important publications in

medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care pract ...

, is organized by field. Some reasons why a particular publication might be regarded as important: *Topic creator – A publication that created a new topic *Breakthrough – A publication that changed scientific knowledge significantly *Influence – A publication which has significantly influenced the world or has had a massive impact on the teaching of medicine. The definitive bibliographic source of books and articles demonstrating the history of medicine and identifying the first publications in the field is "Garrison and Morton". (Morton, Leslie T. (Leslie Thomas), Morton's medical bibliography : an annotated check-list of texts illustrating the history of medicine (Garrison and Morton). -- 5th ed. / edited by Jeremy M. Norman. -- Aldershot, Hants, England ; Brookfield, Vt., USA : Scolar Press, Gower, c1991. xxiv, 1243 p. .) It is also available electronically, for a fee.

Foundations

''De Materia Medica'' :Author:

Pedanius Dioscorides Pedanius Dioscorides ( grc-gre, Πεδάνιος Διοσκουρίδης, ; 40–90 AD), “the father of pharmacognosy”, was a Greek physician, pharmacologist, botanist, and author of ''De materia medica'' (, On Medical Material) —a 5-vol ...

:Publication data: ''

De Materia Medica (Latin name for the Greek work , , both meaning "On Medical Material") is a pharmacopoeia of medicinal plants and the medicines that can be obtained from them. The five-volume work was written between 50 and 70 CE by Pedanius Dioscorides, a ...

'', 50–70 :Online version:''
Online version of first volume
:Description: This five-volume work was a precursor to all modern

pharmacopeia A pharmacopoeia, pharmacopeia, or pharmacopoea (from the obsolete typography ''pharmacopœia'', meaning "drug-making"), in its modern technical sense, is a book containing directions for the identification of compound medicines, and published by ...

s. In fact, it remained in use until the 16th century, though with some additional commentary and additions from

Arabian The Arabian Peninsula, (; ar, شِبْهُ الْجَزِيرَةِ الْعَرَبِيَّة, , "Arabian Peninsula" or , , "Island of the Arabs") or Arabia, is a peninsula of Western Asia, situated northeast of Africa on the Arabian Plate. ...

and

Indian Indian or Indians may refer to: Peoples South Asia * Indian people, people of Indian nationality, or people who have an Indian ancestor ** Non-resident Indian, a citizen of India who has temporarily emigrated to another country * South Asia ...

sources. :Importance: Topic creator, Breakthrough, Impact ''The Canon of Medicine'' :Author:

Avicenna Ibn Sina ( fa, ابن سینا; 980 – June 1037 CE), commonly known in the West as Avicenna (), was a Persian polymath who is regarded as one of the most significant physicians, astronomers, philosophers, and writers of the Islamic G ...

(Ibn Sina) :Publication data: ''

The Canon of Medicine ''The Canon of Medicine'' ( ar, القانون في الطب, italic=yes ''al-Qānūn fī al-Ṭibb''; fa, قانون در طب, italic=yes, ''Qanun-e dâr Tâb'') is an encyclopedia of medicine in five books compiled by Persian physician-phi ...

'', 1025 :Description: This fourteen-volume

medical encyclopedia A medical encyclopaedia is a comprehensive written compendium that holds information about diseases, medical conditions, tests, symptoms, injuries, and surgeries. It may contain an extensive gallery of medicine-related photographs and illustration ...

was the first of its kind and remained the most popular medical textbook in both

Europe Europe is a large peninsula conventionally considered a continent in its own right because of its great physical size and the weight of its history and traditions. Europe is also considered a Continent#Subcontinents, subcontinent of Eurasia ...

and the

Islamic world The terms Muslim world and Islamic world commonly refer to the Islamic community, which is also known as the Ummah. This consists of all those who adhere to the religious beliefs and laws of Islam or to societies in which Islam is practiced. In ...

up until the 17th century and continued to be in use as late as the 19th century. Among other things, the book is known for the discovery of

contagious diseases An infection is the invasion of tissue (biology), tissues by pathogens, their multiplication, and the reaction of host (biology), host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmiss ...

, and the introduction of

experimental medicine An experimental drug is a medicinal product (a drug or vaccine) that has not yet received approval from governmental regulatory authorities for routine use in human or veterinary medicine. A medicinal product may be approved for use in one disea ...

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...

randomized controlled trial A randomized controlled trial (or randomized control trial; RCT) is a form of scientific experiment used to control factors not under direct experimental control. Examples of RCTs are clinical trials that compare the effects of drugs, surgical te ...

efficacy Efficacy is the ability to perform a task to a satisfactory or expected degree. The word comes from the same roots as ''effectiveness'', and it has often been used synonymously, although in pharmacology a pragmatic clinical trial#Efficacy versu ...

tests, and

clinical pharmacology Clinical pharmacology has been defined as "that discipline that teaches, does research, frames policy, gives information and advice about the actions and proper uses of medicines in humans and implements that knowledge in clinical practice". Clinic ...

. The work is considered one of the most famous books in the

history of medicine The history of medicine is both a study of medicine throughout history as well as a multidisciplinary field of study that seeks to explore and understand medical practices, both past and present, throughout human societies. More than just histo ...

. :Importance: Topic creator, Breakthrough, Impact ''

Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus ''Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus'' (Latin, 'An Anatomical Exercise on the Motion of the Heart and Blood in Living Beings'), commonly called ''De Motu Cordis'', is the best-known work of the physician William Harv ...

'' :Author:

William Harvey William Harvey (1 April 1578 – 3 June 1657) was an English physician who made influential contributions in anatomy and physiology. He was the first known physician to describe completely, and in detail, the systemic circulation and proper ...

:Publication data: 1628 :Description: The work in which Harvey explained the

circulation of the blood The blood circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate. It includes the cardiovascular system, or vascular system, tha ...

. :Importance: Breakthrough, Impact ''The Principles and Practice of Medicine: Designed for the Use of Practitioners and Students of Medicine'' :Author:

William Osler Sir William Osler, 1st Baronet, (; July 12, 1849 – December 29, 1919) was a Canadian physician and one of the "Big Four" founding professors of Johns Hopkins Hospital. Osler created the first Residency (medicine), residency program for spec ...

:Publication data: :Online version: :Description: First published in 1892 while Osler was Professor of Medicine at

Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hem ...

, this textbook was, in its time, translated into French, German, Russian, Portuguese, Spanish and Chinese. It became the most significant medical textbook of the next 40 years.Golden, Richard L. A history of William Osler's The principles and practice of medicine. Montreal, Quebec : Osler Library, McGill University, 2004. Osler Library studies in the history of medicine ; no. 8. :Importance: Impact

Recent studies

''Mortality in relation to smoking: 50 years' observation on male British doctors'' :Authors: R. Doll, R. Peto, J. Boreham, I. Sutherland :Publication data: ''

BMJ ''The BMJ'' is a weekly peer-reviewed medical trade journal, published by the trade union the British Medical Association (BMA). ''The BMJ'' has editorial freedom from the BMA. It is one of the world's oldest general medical journals. Origina ...

'' 2004;328:1519–33. :Description: This is the British doctors study. A prospective

cohort study A cohort study is a particular form of longitudinal study that samples a cohort (a group of people who share a defining characteristic, typically those who experienced a common event in a selected period, such as birth or graduation), performing ...

which ran from 1951 to 2001, and in 1956 provided convincing statistical evidence that

tobacco smoking Tobacco smoking is the practice of burning tobacco and ingesting the resulting smoke. The smoke may be inhaled, as is done with cigarettes, or simply released from the mouth, as is generally done with pipes and cigars. The practice is believed ...

increases the risk of

lung cancer Lung cancer, also known as lung carcinoma (since about 98–99% of all lung cancers are carcinomas), is a malignant lung tumor characterized by uncontrolled cell growth in tissue (biology), tissues of the lung. Lung carcinomas derive from tran ...

. :Importance: Impact ''Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study'' :Authors: The

Scandinavian Simvastatin Survival Study Group A Scandinavian is a resident of Scandinavia or something associated with the region, including: Culture * Scandinavianism, political and cultural movement * Scandinavian design, a design movement of the 1950s * Scandinavian folklore * Scandinavi ...

. :Publication data: '' Lancet'' 1994;344:1383–1389 :Description: The

Scandinavian Simvastatin Survival Study The Scandinavian Simvastatin Survival Study (also known as the 4S study), was a multicentre, randomized, double-blind, placebo-controlled clinical trial, which provided the initial data that supported the use of the cholesterol-lowering drug, sim ...

(also known under the abbreviation ''4S'') is a multicenter

that was performed in the 1990s in

Scandinavia Scandinavia; Sámi languages: /. ( ) is a subregion#Europe, subregion in Northern Europe, with strong historical, cultural, and linguistic ties between its constituent peoples. In English usage, ''Scandinavia'' most commonly refers to Denmark, ...

. The objective of the study was to assess the effect of a

cholesterol Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell mem ...

-lowering drug called

simvastatin Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. It is also used to decrease the risk of heart ...

mortality Mortality is the state of being mortal, or susceptible to death; the opposite of immortality. Mortality may also refer to: * Fish mortality, a parameter used in fisheries population dynamics to account for the loss of fish in a fish stock throug ...

and

morbidity A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that a ...

in group of 4444 patients with

coronary heart disease Coronary artery disease (CAD), also called coronary heart disease (CHD), ischemic heart disease (IHD), myocardial ischemia, or simply heart disease, involves the reduction of blood flow to the heart muscle due to build-up of atherosclerotic pla ...

, aged between 35 and 70 years. The patients presented with moderate

hypercholesterolemia Hypercholesterolemia, also called high cholesterol, is the presence of high levels of cholesterol in the blood. It is a form of hyperlipidemia (high levels of lipids in the blood), hyperlipoproteinemia (high levels of lipoproteins in the blood), ...

between 5.5 and 8.0 mmol/L. The results of the trial showed that simvastatin had a lowering effect on mortality and morbidity of patients with coronary heart disease. :Importance: Impact ''Heart Protection Study'' :Authors: Medical Research Council :Online version:''
Research site
:Description: The

Heart Protection Study The Heart Protection Study was a randomized controlled trial run by the Clinical Trial Service Unit, and funded by the Medical Research Council (UK), Medical Research Council (MRC) and the British Heart Foundation (BHF) in the United Kingdom. It st ...

is a large

by the Medical Research Council (MRC) in the

United Kingdom The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Europe, off the north-western coast of the continental mainland. It comprises England, Scotland, Wales and North ...

. It studies the use of

statin Statins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications that reduce illness and mortality in those who are at high risk of cardiovascular disease. They are the most common cholesterol-lowering drugs. Low- ...

(

40 mg)

medication A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and re ...

and

vitamin A vitamin is an organic molecule (or a set of molecules closely related chemically, i.e. vitamers) that is an Nutrient#Essential nutrients, essential micronutrient that an organism needs in small quantities for the proper functioning of its ...

supplementation (

vitamin E Vitamin E is a group of eight fat soluble compounds that include four tocopherols and four tocotrienols. Vitamin E deficiency, which is rare and usually due to an underlying problem with digesting dietary fat rather than from a diet low in vitami ...

vitamin C Vitamin C (also known as ascorbic acid and ascorbate) is a water-soluble vitamin found in citrus and other fruits and vegetables, also sold as a dietary supplement and as a topical 'serum' ingredient to treat melasma (dark pigment spots) an ...

and

beta carotene Beta (, ; uppercase , lowercase , or cursive Greek, cursive ; grc, βῆτα, bē̂ta or ell, βήτα, víta) is the second letter of the Greek alphabet. In the system of Greek numerals, it has a value of 2. In Modern Greek, it represents th ...

) in patients that are at risk for

cardiovascular disease Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, h ...

. :Importance: Impact

Publications in medicine by field

Cardiology Cardiology () is a branch of medicine that deals with disorders of the heart and the cardiovascular system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular heart d ...

''Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction'' :Authors: Moss AJ, Zareba W, Hall WJ, Klein H, Wilber DJ, Cannom DS, Daubert JP, Higgins SL, Brown MW, Andrews ML; Multicenter Automatic Defibrillator Implantation Trial II Investigators. :Publication data:

N Engl J Med ''The New England Journal of Medicine'' (''NEJM'') is a weekly medical journal published by the Massachusetts Medical Society. It is among the most prestigious peer-reviewed medical journals as well as the oldest continuously published one. Hist ...

. 2002 Mar 21;346(12):877-83. Epub 2002 Mar 19. (MADIT 2) :Description: This study shows that anyone with

and decreased

ejection fraction An ejection fraction (EF) is the volumetric fraction (or portion of the total) of fluid (usually blood) ejected from a chamber (usually the heart) with each contraction (or heartbeat). It can refer to the cardiac atrium, ventricle, gall bladder, ...

should receive an

implantable cardioverter-defibrillator An implantable cardioverter-defibrillator (ICD) or automated implantable cardioverter defibrillator (AICD) is a device implantable inside the body, able to perform defibrillation, and depending on the type, cardioversion and pacing of the ...

. :Importance: Impact

Endocrinology Endocrinology (from '' endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental event ...

''Pancreatic extracts in the treatment of

diabetes mellitus Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

'' :Author: Banting FG, Best CH, Collip JB, Campbell WR, Fletcher AA :Publication data: Canadian Medical Association Journal 1922;12:141-146. :Online version:''
Online version
:Description: Banting and Best proved the existence of the hypothetical pancreatic substance termed "

insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism o ...

" by Sharpey-Schafer. :Importance: Topic creator, Breakthrough, Impact ''Diabetes mellitus: its differentiation into insulin-sensitive and insulin-insensitive types.'' :Author: Himsworth HP :Publication data: Lancet 1936;i:127-130. :Online version: :Description: Himsworth noted that there are two main types of diabetes, the insulin-depleted (type 1) and the insulin-resistant form (type 2).

Insulin resistance Insulin resistance (IR) is a pathological condition in which cell (biology), cells fail to respond normally to the hormone insulin. Insulin is a hormone that facilitates the transport of glucose from blood into cells, thereby reducing blood gluco ...

is a term and concept of his coinage. :Importance: Breakthrough, Impact

References

{{DEFAULTSORT:List Of Important Publications In Medicine

Medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care pract ...

Medical publishing Publications In Medicine

Publications To publish is to make content available to the general public.Berne Conve ...