The List of McDonnell Douglas MD-80 operators lists the current operators of the aircraft, and any of its variants. As of December 2020, a total of 149 MD-80 aircraft (all variants) were in active service.[1]
| Airline | MD81 | MD82 | MD83 | MD87 | MD88 | Total |
|---|---|---|---|---|---|---|
| Aeronaves TSM | 4 | 9 | 13 | |||
| Aeropostal | 2 | 2 | ||||
| African Express Airways | 2 | 2 | ||||
| Airfast Indonesia | 2 | 2 | 4 | |||
| ALK Airlines | 2 | 2 | ||||
| AMAC Aerospace | 1 | 1 | ||||
| Amjet Executive | 1 | 1 | ||||
| Andes Líneas Aéreas | 4 | 4 | ||||
| ATA Airlines | 1 | 8 | 9 | |||
| Bravo Airways | 2 | 1 | 3 | |||
| Bukovyna Airlines | 1 | 1 | ||||
| Bulgarian Air Charter | 9 | 9 | ||||
| Canadian Airways Congo | 1 | 1 | 2 | |||
| Caspian Airlines | 5 | 5 | ||||
| Chadian Government | 1 | 1 | ||||
| Dana Air | 1 | 5 | 6 | |||
| Danish Air Transport | 2 | 1 | 3 | |||
| Detroit Pistons | 1 | 1 | ||||
| Erickson Aero Tanker | 1 | 7 | 8 | |||
| Eswatini Government | 1 | 1 | ||||
| Everts Air | 1 | 4 | 5 | |||
| Iran Air | 2 | 2 | ||||
| Iran Air Tours | 4 | 1 | 5 | |||
| Kam Air | 1 | 1 | 2 | 4 | ||
| Katana Wings | 1 | 1 | ||||
| KEB Aircraft | 1 | 1 | ||||
| Kish Air | 4 | 3 | 7 | |||
| LASER Airlines | 4 | 6 | 2 | 12 | ||
| Montavachi Limited | 1 | 1 | ||||
| Olympia Aviation | 1 | 1 | ||||
| Sunrider Corporation | 1 | 1 | ||||
| Taban Air | 5 | 5 | ||||
| Taftan Airlines | 1 | 1 | 2 | |||
| TezJet Air | 1 | 1 | ||||
| Unidentified | 1 | 1 | ||||
| USA Jet Airlines | 1 | 1 | ||||
| Venezolana | 1 | 1 | 2 | |||