Lexitropsins are members of a family of
semi-synthetic
Semisynthesis, or partial chemical synthesis, is a type of chemical synthesis that uses chemical compounds isolated from natural sources (such as microbial cell cultures or plant material) as the starting materials to produce novel compounds with ...
DNA-binding
ligand
In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's electr ...
s. They are
structural analog
A structural analog (analogue in modern traditional English; Commonwealth English), also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a ce ...
s of the natural antibiotics
netropsin
Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. Netropsin was discovered by Finlay ''et al.'', and first isolated from the actinobacterium '' Streptomyces netropsis''. It belongs to the clas ...
and
distamycin
Distamycin is a polyamide-antibiotic, which acts as a minor groove binder, binding to the small furrow of the double helix.
Properties
Distamycin is a pyrrole- amidine antibiotic and analogous to netropsin and the class of lexitropsins. As o ...
. Antibiotics of this group can bind in the minor groove of DNA with different sequence-selectivity. Lexitropsins form a complexes with DNA with
stoichiometry
Stoichiometry refers to the relationship between the quantities of reactants and products before, during, and following chemical reactions.
Stoichiometry is founded on the law of conservation of mass where the total mass of the reactants equal ...
1:1 and 2:1. Based on the 2:1 complexes were obtained ligands with high sequence-selectivity.
See also
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Hoechst 33258
Hoechst stains are part of a family of blue fluorescent dyes used to stain DNA. These bis-benzimides were originally developed by Hoechst AG, which numbered all their compounds so that the dye Hoechst 33342 is the 33,342nd compound made by the ...
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Pentamidine
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DNA binding ligand
DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA. Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA, becaus ...
*
Single-strand binding protein Single-strand DNA-binding protein (SSB) is a protein found in ''Escherichia coli'' (''E. coli'') bacteria, that binds to single-stranded regions of deoxyribonucleic acid ( DNA). Single-stranded DNA is produced during all aspects of DNA metabolism: ...
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Comparison of nucleic acid simulation software
This is a list of notable computer programs that are used for nucleic acids simulations.
See also
References
Computational chemistry software
Software comparisons
Molecular dynamics software
Molecular modelling software
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References
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Molecular biology
DNA-binding substances