Membrane dipeptidase (, ''renal dipeptidase'', ''dehydropeptidase I (DPH I)'', ''dipeptidase'', ''aminodipeptidase'', ''dipeptide hydrolase'', ''dipeptidyl hydrolase'', ''nonspecific dipeptidase'', ''glycosyl-phosphatidylinositol-anchored renal dipeptidase'', ''MBD'', ''MDP'', ''leukotriene D
4 hydrolase'') is an
enzyme.
This enzyme
catalyses the following
chemical reaction
:
Hydrolysis of
dipeptides A dipeptide is an organic compound derived from two amino acids. The constituent amino acids can be the same or different. When different, two isomers of the dipeptide are possible, depending on the sequence. Several dipeptides are physiologicall ...
(e.g.,
leukotriene D4,
cystinyl-bis-glycine, some
β-lactam antibiotics (e.g.,
carbapenem))
This membrane-bound, zinc enzyme has broad specificity.
Inhibitor
Inhibitor or inhibition may refer to:
In biology
* Enzyme inhibitor, a substance that binds to an enzyme and decreases the enzyme's activity
* Reuptake inhibitor, a substance that increases neurotransmission by blocking the reuptake of a neurotra ...
s include
bestatin and
cilastatin
Cilastatin inhibits the human enzyme dehydropeptidase.
Uses
Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to ...
.
Genes
*
Dipeptidase 1
Dipeptidase 1 (DPEP1), or renal dipeptidase, is a membrane-bound glycoprotein responsible for Hydrolysis, hydrolyzing dipeptides. It is found in the Microsome, microsomal fraction of the procine kidney cortex. It exists as a disulfide-linked homod ...
(DPEP1)
*
Dipeptidase 2 (DPEP2)
*
Dipeptidase 3
Dipeptidase 3 (DPEP3) is a protein that in humans is encoded by the ''DPEP3'' gene.
This gene encodes a membrane-bound glycoprotein from the family of dipeptidases (EC 3.4.13.19) involved in hydrolytic metabolism of various dipeptides, includin ...
(DPEP3)
References
External links
*
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EC 3.4.13