LY-307,452 is a drug used in neuroscience research, which was among the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (Metabotropic glutamate receptor, mGluR_2/3), and was useful in early studies of this receptor family, although it has largely been replaced by newer drugs such as LY-341,495. Its molecular formula is C₂₁H₂₅NO₄

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Drugs developed by Eli Lilly and Company MGlu2 receptor antagonists MGlu3 receptor antagonists {{nervous-system-drug-stub