LY-272,015 is a

beta-carboline β-Carboline (9''H''- pyrido ,4-''b'' ndole) represents the basic chemical structure for more than one hundred alkaloids and synthetic compounds. The effects of these substances depend on their respective substituent. Natural β-carbolines prima ...

derivative drug developed by

Eli Lilly Eli Lilly (July 8, 1838 – June 6, 1898) was an American soldier, pharmacist, chemist, and businessman who founded the Eli Lilly and Company pharmaceutical corporation. Lilly enlisted in the Union Army during the American Civil War and ...

, which acts as a potent and selective antagonist at the serotonin 5-HT_2B

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

. It has anti- hypertensive effects in animal models, and is also used in research into the other functions of the 5-HT_2B receptor.

References

5-HT2B antagonists Beta-Carbolines Tryptamines Eli Lilly and Company brands Phenol ethers {{nervous-system-drug-stub