Broparestrol () (brand names Acnestrol, Longestrol; former developmental code name LN-107), also known as α-bromo-α,β-diphenyl-β-p-ethylphenylethylene (BDPE), is a synthetic compound, synthetic, nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group
that has been used in Europe as a dermatology, dermatological agent and for the treatment of breast cancer.
The drug is described as slightly estrogenic
and potently antiestrogenic,
and inhibits mammary gland development and suppresses prolactin levels in animals.
It is structurally related to clomifene and diethylstilbestrol.
Broparestrol is a mixture of ''E-'' and ''Z-'' isomers (LN-1643 and LN-2299, respectively), both of which are active and are similarly antiestrogenic but, unlike broparestrol, were never marketed.
See also
* List of selective estrogen receptor modulators
References
Abandoned drugs
Organobromides
Selective estrogen receptor modulators
Synthetic estrogens
Triphenylethylenes
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