Ligand-dependent corepressor is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''LCOR''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
LCOR is a transcriptional
corepressor In the field of molecular biology, a corepressor is a molecule that represses the expression of genes. In prokaryotes, corepressors are small molecules whereas in eukaryotes, corepressors are proteins. A corepressor does not directly bind to DNA, ...
widely expressed in fetal and adult tissues that is recruited to agonist-bound
nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.
References
Further reading
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External links
PDBe-KBprovides an overview of all the structure information available in the PDB for Human Ligand-dependent corepressor
Transcription coregulators
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