Ligand-dependent corepressor is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''LCOR''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
LCOR is a transcriptional
corepressor
In genetics and molecular biology, a corepressor is a molecule that represses the expression of genes. In prokaryotes
A prokaryote (; less commonly spelled procaryote) is a single-celled organism whose cell lacks a nucleus and other membra ...
widely expressed in fetal and adult tissues that is recruited to agonist-bound
nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These intracellular receptors work with other proteins to regulate the ex ...
s through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.
References
Further reading
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External links
PDBe-KBprovides an overview of all the structure information available in the PDB for Human Ligand-dependent corepressor
Transcription coregulators
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