Kurt Wüthrich (born 4 October 1938 in Aarberg,

Canton of Bern The canton of Bern or Berne (german: Kanton Bern; rm, Chantun Berna; french: canton de Berne; it, Canton Berna) is one of the 26 cantons forming the Swiss Confederation. Its capital city, Bern, is also the ''de facto'' capital of Switzerland. ...

) is a

Swiss Swiss may refer to: * the adjectival form of Switzerland *Swiss people Places * Swiss, Missouri *Swiss, North Carolina * Swiss, West Virginia *Swiss, Wisconsin Other uses * Swiss-system tournament, in various games and sports * Swiss Internation ...

chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe th ...

biophysicist Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Bi ...

and Nobel Chemistry laureate, known for developing

nuclear magnetic resonance Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a ...

(NMR) methods for studying biological

macromolecules A macromolecule is a very large molecule important to biophysical processes, such as a protein or nucleic acid. It is composed of thousands of covalently bonded atoms. Many macromolecules are polymers of smaller molecules called monomers. The ...

Education and early life

Born in Aarberg,

Switzerland ). Swiss law does not designate a ''capital'' as such, but the federal parliament and government are installed in Bern, while other federal institutions, such as the federal courts, are in other cities (Bellinzona, Lausanne, Luzern, Neuchâtel ...

, Wüthrich was educated in

chemistry Chemistry is the scientific study of the properties and behavior of matter. It is a natural science that covers the elements that make up matter to the compounds made of atoms, molecules and ions: their composition, structure, proper ...

physics Physics is the natural science that studies matter, its fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge which ...

, and

mathematics Mathematics is an area of knowledge that includes the topics of numbers, formulas and related structures, shapes and the spaces in which they are contained, and quantities and their changes. These topics are represented in modern mathematics ...

at the

University of Bern The University of Bern (german: Universität Bern, french: Université de Berne, la, Universitas Bernensis) is a university in the Swiss capital of Bern and was founded in 1834. It is regulated and financed by the Canton of Bern. It is a compreh ...

before pursuing his

PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * '' Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. al ...

supervised by Silvio Fallab at the

University of Basel The University of Basel (Latin: ''Universitas Basiliensis'', German: ''Universität Basel'') is a university in Basel, Switzerland. Founded on 4 April 1460, it is Switzerland's oldest university and among the world's oldest surviving universiti ...

, awarded in 1964.

Career

After his PhD, Wüthrich continued

postdoctoral research A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pu ...

with Fallab for a short time before leaving to work at the

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant un ...

for two years from 1965 with Robert E. Connick. That was followed by a stint working with Robert G. Shulman at the

Bell Telephone Laboratories Nokia Bell Labs, originally named Bell Telephone Laboratories (1925–1984), then AT&T Bell Laboratories (1984–1996) and Bell Labs Innovations (1996–2007), is an American industrial research and scientific development company owned by mult ...

Murray Hill, New Jersey Murray Hill is an unincorporated community located within portions of both Berkeley Heights and New Providence, located in Union County in northern New Jersey, United States. It is the longtime central location of Bell Labs (part of Nokia s ...

from 1967 to 1969. Wüthrich returned to Switzerland, to

Zürich , neighboring_municipalities = Adliswil, Dübendorf, Fällanden, Kilchberg, Maur, Oberengstringen, Opfikon, Regensdorf, Rümlang, Schlieren, Stallikon, Uitikon, Urdorf, Wallisellen, Zollikon , twintowns = Kunming, San Francisco Z ...

, in 1969, where he began his career there at the ETH Zürich, rising to Professor of Biophysics by 1980. He currently maintains a laboratory at the ETH Zürich, at

The Scripps Research Institute Scripps Research, previously known as The Scripps Research Institute (TSRI), is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the instit ...

, in

La Jolla, California La Jolla ( , ) is a hilly, seaside neighborhood within the city of San Diego, California, United States, occupying of curving coastline along the Pacific Ocean. The population reported in the 2010 census was 46,781. La Jolla is surrounded on ...

and at the of ShanghaiTech University. He has also been a visiting professor at the

University of Edinburgh The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 1 ...

(1997–2000), the

Chinese University of Hong Kong The Chinese University of Hong Kong (CUHK) is a public research university in Ma Liu Shui, Hong Kong, formally established in 1963 by a charter granted by the Legislative Council of Hong Kong. It is the territory's second-oldest university and ...

(where he was an Honorary Professor) and

Yonsei University Yonsei University (; ) is a private research university in Seoul, South Korea. As a member of the " SKY" universities, Yonsei University is deemed one of the three most prestigious institutions in the country. It is particularly respected in th ...

. During his graduate studies Wüthrich started out working with

electron paramagnetic resonance Electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy is a method for studying materials that have unpaired electrons. The basic concepts of EPR are analogous to those of nuclear magnetic resonance (NMR), but the spin ...

spectroscopy, and the subject of his PhD thesis was "the

catalytic Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...

activity of

copper Copper is a chemical element with the symbol Cu (from la, cuprum) and atomic number 29. It is a soft, malleable, and ductile metal with very high thermal and electrical conductivity. A freshly exposed surface of pure copper has a pink ...

compounds in autoxidation reactions". During his time as a

postdoc A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pu ...

in Berkeley he began working with the newly developed and related technique of

nuclear magnetic resonance spectroscopy Nuclear magnetic resonance spectroscopy, most commonly known as NMR spectroscopy or magnetic resonance spectroscopy (MRS), is a spectroscopic technique to observe local magnetic fields around atomic nuclei. The sample is placed in a magnetic fie ...

to study the hydration of

metal complexes A coordination complex consists of a central atom or ion, which is usually metallic and is called the ''coordination centre'', and a surrounding array of bound molecules or ions, that are in turn known as ''ligands'' or complexing agents. Many ...

. When Wüthrich joined the Bell Labs, he was put in charge of one of the first

superconducting Superconductivity is a set of physical properties observed in certain materials where electrical resistance vanishes and magnetic flux fields are expelled from the material. Any material exhibiting these properties is a superconductor. Unlike ...

NMR spectrometers, and started studying the structure and dynamics of proteins. He has pursued this line of research ever since. After returning to Switzerland, Wüthrich collaborated with, among others, Nobel laureate

Richard R. Ernst Richard Robert Ernst (14 August 1933 – 4 June 2021) was a Swiss physical chemist and Nobel Laureate. Ernst was awarded the Nobel Prize in Chemistry in 1991 for his contributions towards the development of Fourier transform nuclear magnetic ...

on developing the first two-dimensional NMR experiments, and established the

nuclear Overhauser effect The nuclear Overhauser effect (NOE) is the transfer of nuclear spin polarization from one population of spin-active nuclei (e.g. 1H, 13C, 15N etc.) to another via cross-relaxation. A phenomenological definition of the NOE in nuclear magnetic res ...

as a convenient way of measuring distances within

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

s. This research later led to the complete assignment of resonances for among others the

bovine pancreatic trypsin inhibitor The drug aprotinin (Trasylol, previously Bayer and now Nordic Group pharmaceuticals), is a small protein bovine pancreatic trypsin inhibitor (BPTI), or basic trypsin inhibitor of bovine pancreas, which is an antifibrinolytic molecule that inhibits ...

and

glucagon Glucagon is a peptide hormone, produced by alpha cells of the pancreas. It raises concentration of glucose and fatty acids in the bloodstream, and is considered to be the main catabolic hormone of the body. It is also used as a medication to tre ...

. In October 2010, Wüthrich participated in the USA Science and Engineering Festival's Lunch with a Laureate program where middle and high school students will get to engage in an informal conversation with a Nobel Prize–winning scientist over a brown-bag lunch. Wüthrich is also a member on the USA Science and Engineering Festival's Advisory Board., and a supporter of the

Campaign for the Establishment of a United Nations Parliamentary Assembly Campaign or The Campaign may refer to: Types of campaigns * Campaign, in agriculture, the period during which sugar beets are harvested and processed *Advertising campaign, a series of advertisement messages that share a single idea and theme * Bl ...

, an organisation which campaigns for democratic reform in the United Nations.

Awards and honors

He was awarded the

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemis ...

from

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

in 1991, the Louis-Jeantet Prize for Medicine in 1993, the Otto Warburg Medal in 1999 and half of the

Nobel Prize in Chemistry ) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "M ...

in 2002 for "his development of

spectroscopy Spectroscopy is the field of study that measures and interprets the electromagnetic spectra that result from the interaction between electromagnetic radiation and matter as a function of the wavelength or frequency of the radiation. Matter ...

for determining the three-dimensional structure of biological macromolecules in solution". He received the Bijvoet Medal of the Bijvoet Center for Biomolecular Research of

Utrecht University Utrecht University (UU; nl, Universiteit Utrecht, formerly ''Rijksuniversiteit Utrecht'') is a public research university in Utrecht, Netherlands. Established , it is one of the oldest universities in the Netherlands. In 2018, it had an enrollme ...

in 2008. He was elected a Foreign Member of the Royal Society (ForMemRS) in 2010. He was also awarded the 2018 Fray International Sustainability Award at SIPS 2018 by FLOGEN Star Outreach

Personal details

On 2 April 2018, Dr. Wüthrich established permanent residency in

Shanghai, China Shanghai (; , , Standard Mandarin pronunciation: ) is one of the four direct-administered municipalities of the People's Republic of China (PRC). The city is located on the southern estuary of the Yangtze River, with the Huangpu River flowin ...

, after obtaining a Chinese permanent residence card.

Bibliography

* ''NMR in Biological Research: Peptides and Proteins'', American Elsevier Pub. Co, 1976 * ''NMR of proteins and nucleic acids'', Wiley, 1986 * ''NMR In Structural Biology: A Collection Of Papers By Kurt Wuthrich'', World Scientific Publishing Co Pte Ltd, 1995

References

External links

* including the Nobel Lecture ''NMR Studies of Structure and Function of Biological Macromolecules'' {{DEFAULTSORT:Wuthrich, Kurt 1938 births Living people People from Aarberg ETH Zurich faculty Duke University faculty Academics of the University of Edinburgh Nobel laureates in Chemistry Nuclear magnetic resonance Swiss chemists Swiss biophysicists Swiss Nobel laureates Swiss Protestants Scripps Research faculty Members of the European Molecular Biology Organization Foreign associates of the National Academy of Sciences Members of the French Academy of Sciences Foreign Members of the Royal Society Foreign Fellows of the Indian National Science Academy Bijvoet Medal recipients Kyoto laureates in Advanced Technology University of Bern alumni