Krasnow Institute for Advanced Studies
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The Krasnow Institute for Advanced Study brings together researchers from many disciplines to study the phenomenon known as the mind. A unit of George Mason University, the Krasnow Institute also serves as a center for doctoral education in neuroscience. Research at the institute is funded by agencies such as the
National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...
, the
National Science Foundation The National Science Foundation (NSF) is an independent agency of the United States government that supports fundamental research and education in all the non-medical fields of science and engineering. Its medical counterpart is the National ...
and the
Department of Defense Department of Defence or Department of Defense may refer to: Current departments of defence * Department of Defence (Australia) * Department of National Defence (Canada) * Department of Defence (Ireland) * Department of National Defense (Philipp ...
.


History

The Krasnow Institute was chartered in 1990 as a result of a bequest from Shelley Krasnow, a long-time resident of the National Capital Area. The work of the institute began in 1993 with a scientific conference, co-sponsored with The
Santa Fe Institute The Santa Fe Institute (SFI) is an independent, nonprofit theoretical research institute located in Santa Fe, New Mexico, United States and dedicated to the multidisciplinary study of the fundamental principles of complex adaptive systems, inclu ...
(SFI) and hosted at George Mason University. This conference on "The Mind, the Brain, and Complex Adaptive Systems" brought together an unusual group of scientists including two Nobel laureates (
Murray Gell-Mann Murray Gell-Mann (; September 15, 1929 – May 24, 2019) was an American physicist who received the 1969 Nobel Prize in Physics for his work on the theory of elementary particles. He was the Robert Andrews Millikan Professor of Theoretical ...
and
Herbert A. Simon Herbert Alexander Simon (June 15, 1916 – February 9, 2001) was an American political scientist, with a Ph.D. in political science, whose work also influenced the fields of computer science, economics, and cognitive psychology. His primary ...
) and produced new approaches to this frontier in addition to a book published by SFI. These efforts set the institute on the path of human cognition within the context of the intersection of neuroscience, cognitive psychology and computer sciences.


Current Institute

The Krasnow Institute is home to a scientific community of 100 (many of them Ph.D.'s) most of whom are also either faculty or trainees at George Mason University. The range of their research on cognition spans from molecules to mind. The institute is housed in a dedicated facility on the Fairfax Campus of George Mason which includes extensive wet-laboratories, computer labs, a 3T MRI human brain imaging center, a cellular imaging facility, as well as faculty offices and breakout space. Additional research space on the Fairfax campus houses the institute's Center for Social Complexity.


An Academic Unit of George Mason University

The Krasnow Institute is also an academic unit of George Mason University. It houses the department of Molecular
Neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developme ...
, which plays a key role in the interdisciplinary neuroscience doctoral program. The institute hosted several events in the "
Decade of the Mind The Decade of the Mind Project is an international initiative to advance scientific understanding of how the mind and complex behaviors are related to the activity of human brains. The problem of explaining the mind is so complex as to require ...
" initiative, which urged the U.S. Congress to invest in understanding how mind emerges from brain. The institute has collaborated closely with the
Janelia Research Campus Janelia Research Campus is a scientific research campus of the Howard Hughes Medical Institute that opened in October 2006. The campus is located in Loudoun County, Virginia, near the town of Ashburn. It is known for its scientific research and m ...
of Howard Hughes Medical Institute, the
Allen Institute for Brain Science The Allen Institute for Brain Science is a division of the Allen Institute, based in Seattle, Washington, that focuses on bioscience research. Founded in 2003, it is dedicated to accelerating the understanding of how the human brain works. Wit ...
and the
National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...
to develop better methods of reconstructing neuronal architectures.
Diadem Challenge


Research

Researchers at the institute include neuroscientists, bio-engineers, computer scientists, and computational social scientists. The institute's various research programs are conducted by three centers (described below) and multiple lab groups. Many of the programs focus on research that may lead to cures to some of the most devastating brain diseases.


The Center for Neural Informatics, Neural Structures, and Neural Plasticity (CN3)

The Center for Neural Informatics, Neural Structures, and Neural Plasticity (CN3) pursues fundamental breakthroughs in neuroscience by fostering neuroinformatic and computational approaches to
neuroplasticity Neuroplasticity, also known as neural plasticity, or brain plasticity, is the ability of neural networks in the brain to change through growth and reorganization. It is when the brain is rewired to function in some way that differs from how it p ...
and
neuroanatomy Neuroanatomy is the study of the structure and organization of the nervous system. In contrast to animals with radial symmetry, whose nervous system consists of a distributed network of cells, animals with bilateral symmetry have segregated, defi ...
. By bringing together faculty expertise in these multiple disciplines, the Center provides opportunities for cross-training in
neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developme ...
,
psychology Psychology is the scientific study of mind and behavior. Psychology includes the study of conscious and unconscious phenomena, including feelings and thoughts. It is an academic discipline of immense scope, crossing the boundaries between ...
, and
engineering Engineering is the use of scientific principles to design and build machines, structures, and other items, including bridges, tunnels, roads, vehicles, and buildings. The discipline of engineering encompasses a broad range of more speciali ...
, both at the graduate and postdoctoral levels. CN3 researchers investigate the relationship between
brain A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a ve ...
structure, activity, and function from the subcellular to the network level, with a specific focus on the biophysical and biochemical mechanisms of learning and
memory Memory is the faculty of the mind by which data or information is encoded, stored, and retrieved when needed. It is the retention of information over time for the purpose of influencing future action. If past events could not be remembered ...
. In the long term, we seek to create large-scale, biologically plausible network models of entire portions of the mammalian brain, such as the
hippocampus The hippocampus (via Latin from Greek , ' seahorse') is a major component of the brain of humans and other vertebrates. Humans and other mammals have two hippocampi, one in each side of the brain. The hippocampus is part of the limbic system, ...
, to understand the neural circuits and cellular events underlying the expression, storage, and retrieval of associative
memory Memory is the faculty of the mind by which data or information is encoded, stored, and retrieved when needed. It is the retention of information over time for the purpose of influencing future action. If past events could not be remembered ...
.


Center for Neuroeconomics

Krasnow scientists are using functional magnetic resonance imaging of the human brain to study human interactions within the context of free-markets. These studies allow, for the first time, the elucidation of a biological basis for economic decisions.


Center for Social Complexity (CSC)

Scientific projects at the Center for Social Complexity focus on investigating social systems and processes on multiple scales: groups, organizations, economies, societies, regions, international systems. Researchers use a variety of interdisciplinary tools, including multi-agent systems and agent-based models (including the MASON toolkit in Java),
cellular automata A cellular automaton (pl. cellular automata, abbrev. CA) is a discrete model of computation studied in automata theory. Cellular automata are also called cellular spaces, tessellation automata, homogeneous structures, cellular structures, tessel ...
and other social simulation methods, network and graph-theoretic models, GIS (geographic information systems), events data analysis, complexity-theoretic models and other advanced computational methods. The center houses a specialized simulation environment (the Simulatorium), where faculty, postdoctoral researchers, and graduate research assistants collaborate in a variety of projects. Conflict and cooperation, emergent economic systems, network dynamics, and long-term societal adaptation to environmental change are among the current lines of investigation. Funding for the center is provided by grants from the US National Science Foundation, the Department of Defense, and other agencies. The center does work in
computational sociology Computational sociology is a branch of sociology that uses computationally intensive methods to analyze and model social phenomena. Using computer simulations, artificial intelligence, complex statistical methods, and analytic approaches like soc ...
.


References


External links

* {{DEFAULTSORT:Kraskow George Mason University Educational institutions established in 1990 Research institutes in Virginia Cognitive science research institutes Artificial intelligence laboratories Laboratories in the United States 1990 establishments in Virginia