Keratin, type I cytoskeletal 17 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''KRT17''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Keratin 17 is a
type I cytokeratin. It is found in
nail beds,
hair follicle
The hair follicle is an organ found in mammalian skin. It resides in the dermal layer of the skin and is made up of 20 different cell types, each with distinct functions. The hair follicle regulates hair growth via a complex interaction between ...
s,
sebaceous gland
A sebaceous gland is a microscopic exocrine gland in the skin that opens into a hair follicle to secrete an oily or waxy matter, called sebum, which lubricates the hair and skin of mammals. In humans, sebaceous glands occur in the greatest n ...
s, and other epidermal appendages. Mutations in the gene encoding this protein lead to PC-K17 (previously known as Jackson-Lawler) type
pachyonychia congenita and
steatocystoma multiplex.
Interactions
Keratin 17 has been shown to
interact
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with
CCDC85B
Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the ''CCDC85B'' gene.
Function
Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. ...
.
References
Further reading
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External links
GeneReviews/NCBI/NIH/UW entry on Pachyonychia Congenita
Keratins
{{gene-17-stub