Krueppel-like factor 5 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''KLF5''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...
.
Interactions
KLF5 has been shown to
interact
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with
Protein SET
Protein SET, also known as Protein SET 1, is a protein that in humans is encoded by the ''SET'' gene.
Interactions
Protein SET has been shown to interact with:
* Acidic leucine-rich nuclear phosphoprotein 32 family member A,
* CDK5R1,
* KLF5 ...
.
See also
*
Kruppel-like factors
In molecular genetics, the Krüppel-like family of transcription factors (KLFs) are a set of eukaryotic C2H2 zinc finger DNA-binding proteins that regulate gene expression. This family has been expanded to also include the Sp transcription factor a ...
References
Further reading
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External links
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Transcription factors
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