Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''WWC1''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Research on human memory
A single nucleotide
polymorphism (rs17070145)
in the gene has been associated with
human memory
Memory is the faculty of the mind by which data or information is encoded, stored, and retrieved when needed. It is the retention of information over time for the purpose of influencing future action. If past events could not be remembered, ...
performance in one 2006 study.
While no significant support for KIBRA's association with memory was found in a 2008 study with 584 subjects,
the original 2006 study was replicated in a smaller sample of an elderly population in 2008.
A subsequent study in 2009 in two large UK samples indicated that ''KIBRA'' is specifically associated with forgetting of non-semantic material.
Studies have also begun to investigate the role of KIBRA in
Alzheimer's disease.
[
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Interactions
''KIBRA'' has at least 10 interaction partners, including
synaptopodin,
PKCζ
Protein kinase C, zeta (PKCζ), also known as PRKCZ, is a protein in humans that is encoded by the ''PRKCZ'' gene. The PRKCZ gene encodes at least two alternative transcripts, the full-length PKCζ and an N-terminal truncated form PKMζ. PKMζ i ...
and
Dendrin
Dendrin is a neural and renal protein whose exact function is still relatively unclear; however, its location in the brain and kidneys is well known as are some of the neural processes it affects. Within the brain, dendrin can be found in neuro ...
, most of which modify synaptic plasticity.
For instance, Dendrin is a post-synaptic protein with expression regulated by sleep deprivation.
''KIBRA'' has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
Protein kinase Mζ
Protein kinase C, zeta (PKCζ), also known as PRKCZ, is a protein in humans that is encoded by the ''PRKCZ'' gene. The PRKCZ gene encodes at least two alternative transcripts, the full-length PKCζ and an N-terminal truncated form PKMζ. PKMζ i ...
.
References
Further reading
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External links
Division of Cognitive Neuroscience, University of Basel, Switzerland
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