John E. Franz
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John E. Franz (born December 21, 1929) is an organic chemist who discovered the herbicide
glyphosate Glyphosate (IUPAC name: ''N''-(phosphonomethyl)glycine) is a broad-spectrum Herbicide, systemic herbicide and Crop desiccation, crop desiccant. It is an organophosphorus compound, specifically a phosphonate, which acts by inhibiting the plan ...
while working at
Monsanto Company The Monsanto Company () was an American agrochemical and agricultural biotechnology corporation founded in 1901 and headquartered in Creve Coeur, Missouri. Monsanto's best known product is Roundup (herbicide), Roundup, a glyphosate-based herbic ...
in 1970.US Patent 3,799,758
/ref> The chemical became the active ingredient in
Roundup A roundup is a systematic gathering together of people or things. Roundup, Round Up or Round-up may also refer to: Agriculture * A muster (livestock) (AU/NZ) or a roundup (US/CA) is the process of gathering livestock. * Roundup (herbicide), a M ...
, a broad-spectrum, post-emergence herbicide. Franz has earned much acclaim and many rewards for this breakthrough. He also has over 840 patents to his name worldwide.


Career

Franz has spent his entire career at Monsanto in
St. Louis, Missouri St. Louis () is the second-largest city in Missouri, United States. It sits near the confluence of the Mississippi River, Mississippi and the Missouri Rivers. In 2020, the city proper had a population of 301,578, while the Greater St. Louis, ...
. After finishing his Ph.D., Franz was hired by Monsanto as a Resident Chemist in 1955.Lemelson-MIT Program.
Inventor of the Week: John Franz
/ref> He focused on process research, new
polymer A polymer (; Greek '' poly-'', "many" + ''-mer'', "part") is a substance or material consisting of very large molecules called macromolecules, composed of many repeating subunits. Due to their broad spectrum of properties, both synthetic a ...
synthesis, and the development of plasticizers and polymer flame retardants.Strong, Colby
People: Monsanto Scientist John E. Franz Wins 1990 Perkins Medal for Applied Chemistry
The Scientist 10 (1990): 28
Monsanto
Biography of Dr. John Franz
/ref> Franz received two patents while working in the organic division, one for
nitrates Nitrate is a polyatomic ion with the chemical formula . Salts containing this ion are called nitrates. Nitrates are common components of fertilizers and explosives. Almost all inorganic nitrates are soluble in water. An example of an insoluble ...
in 1960, and one for a fire retardant in 1967. He transferred to the Agricultural Division of Monsanto in 1967, motivated by the department's "emphasis on publishing, academic contacts, and the freedom to pursue ideas" (Monsanto biography). Because his background was in
organic chemistry Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; ...
, Franz familiarized himself with the new field by spending a year studying and learning about plant physiology and biochemistry before beginning research. Franz discovered the herbicide
glyphosate Glyphosate (IUPAC name: ''N''-(phosphonomethyl)glycine) is a broad-spectrum Herbicide, systemic herbicide and Crop desiccation, crop desiccant. It is an organophosphorus compound, specifically a phosphonate, which acts by inhibiting the plan ...
, and received five dollars for his first patent from Monsanto. From 1960 to 1988, he received over 840 patents worldwide including approximately fifty in the United States. Over the course of his career, Franz published over forty papers and wrote the book ''Glyphosate: A Unique Global Herbicide'' with Michael K. Mao and James A. Sikorski. He was promoted to Senior Scientific Fellow in 1975, then Distinguished Fellow in 1980, and later in his career went back to the organic division to concentrate on environmentally friendly products until he retired in 1991.


Discovery of glyphosate

Researchers at Monsanto had been searching for an herbicide that was effective against annual and perennial weeds for nine years but found little success. They knew of two phosphonic acid compounds that were ineffective against weeds, and the researchers were not able to advance the compounds. Franz took over the research in 1969 and incorrectly hypothesized that the
phosphonic acids In organic chemistry, phosphonates or phosphonic acids are organophosphorus compounds containing groups (where R = alkyl, aryl, or just hydrogen). Phosphonic acids, typically handled as salts, are generally nonvolatile solids that are poorly ...
acted as proherbicides that were metabolized to active compounds rather than herbicides. Franz and his research team screened possible metabolites and synthesized compounds and eventually discovered
glyphosate Glyphosate (IUPAC name: ''N''-(phosphonomethyl)glycine) is a broad-spectrum Herbicide, systemic herbicide and Crop desiccation, crop desiccant. It is an organophosphorus compound, specifically a phosphonate, which acts by inhibiting the plan ...
in 1970. Although all of the patents regarding glyphosate list Franz as the sole inventor and the Monsanto Company as the assignee, Franz acknowledged that the discovery was a group effort. In 2007, when he was inducted into the
National Inventor's Hall of Fame The National Inventors Hall of Fame (NIHF) is an American not-for-profit organization, founded in 1973, which recognizes individual engineers and inventors who hold a U.S. patent of significant technology. Besides the Hall of Fame, it also opera ...
, Franz said, "It's a recognition of the entire team of scientists who worked on and supported the development of Roundup herbicides".
Glyphosate Glyphosate (IUPAC name: ''N''-(phosphonomethyl)glycine) is a broad-spectrum Herbicide, systemic herbicide and Crop desiccation, crop desiccant. It is an organophosphorus compound, specifically a phosphonate, which acts by inhibiting the plan ...
works by absorption through leaves, and then moving rapidly to a plant's roots, rhizomes, and meristems. This invaluable breakthrough immediately spurred Monsanto to design and produce plants genetically immune to glyphosates in order to make it easier for farmers to thoroughly spray down their fields for weeds without killing their own crops. Once glyphosate was invented, it took four years to reach the market. It was first introduced as "Roundup", and is still best known by that brand. Glyphosate has been called by experts in herbicides "virtually ideal" due to its broad spectrum and low toxicity compared with other herbicides.Monsanto's John E. Franz Wins 1990 Perkin Medal
Chem. Eng. News, 1990, 68 (11), pp 29–30 DOI: 10.1021/cen-v068n011.p029
However, the chemical’s use has come under attack in numerous countries, with bans or partial bans enacted, and thousands of lawsuits filed alleging the chemical is carcinogenic. German Chancellor
Angela Merkel Angela Dorothea Merkel (; ; born 17 July 1954) is a German former politician and scientist who served as Chancellor of Germany from 2005 to 2021. A member of the Christian Democratic Union (CDU), she previously served as Leader of the Oppo ...
stated in June 2019 “We will come to a point where glyphosate isn’t used anymore.”


Other research

Franz undertook research in many areas during his time at Monsanto. Some of his other chemistry research includes antiauxin chemistry (isothiazoles, isoxazoles, pyrazoles), plant chemistry,
cell membrane The cell membrane (also known as the plasma membrane (PM) or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of all cells from the outside environment ( ...
chemistry (glyceride and phospholipid syntheses, liposomes), plant hormone chemistry (abscissic acid analogs, ethylene generators), and nitride sulfide chemistry. He also performed research pertaining to reaction mechanisms,
coenzyme A Coenzyme A (CoA, SHCoA, CoASH) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a subs ...
antimetabolites, biorational design of herbicides, and periselective addition reactions of one- and threedipoles, as well as fundamental organic research.


Honors

Franz has received many awards for his important discovery. In 1977, he was awarded the IR-100 award by Industrial Research magazine. In 1981, he received the first J.F. Queeny Award from Monsanto to honor an invention that was also a commercial success. He was the recipient of the 1987
National Medal of Technology The National Medal of Technology and Innovation (formerly the National Medal of Technology) is an honor granted by the President of the United States to American inventors and innovators who have made significant contributions to the development ...
, one of the few agricultural technologies to ever receive the honor. Franz received the
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all d ...
’s Carothers Award in 1989 for "outstanding contributions and advances in industrial applications of chemistry". In 1990, he was awarded the
Perkin Medal The Perkin Medal is an award given annually by the Society of Chemical Industry (American Section) to a scientist residing in America for an "innovation in applied chemistry resulting in outstanding commercial development." It is considered the h ...
by the American Section of the
Society of Chemical Industry The Society of Chemical Industry (SCI) is a learned society set up in 1881 "to further the application of chemistry and related sciences for the public benefit". Offices The society's headquarters is in Belgrave Square, London. There are semi-in ...
, based on his contributions to the research and development of applied chemistry. Franz also won the Outstanding Achievement Award in 1988, the 1988 Missouri Award, and was named the St. Louis Metropolitan Bar Association Inventor of the Year in 1986. Roundup was named one of the "Top 10 Products That Changed the Face of Agriculture" by the magazine Farm Chemicals in 1994. Franz was inducted into the United States' Inventor's Hall of Fame on May 5, 2007. Monsanto has also created two awards in his honor. On December 8, 1995, the agricultural company introduced the Franz Sustainability Award, which consists of an annual $100,000 prize given to the individual or team that submits the best environmental project for improvement in the areas of conservation, technology, and/or education. Soon after Franz's induction into the Inventors' Hall of Fame in 2007, Monsanto announced a new annual scholarship called the Franz Innovation Award Scholarship. This scholarship is awarded each year to a graduate student taking organic chemistry at the University of Minnesota.


Patents

Franz has over 840 patents to his name concerning glyphosate and lesser known discoveries. Because of the nature of glyphosate, it requires many patents concerning identification, synthesis, and other processes required to produce the chemical. His patents include: * Patent Number: 3799758, Phytotoxicant compositions * Patent Number: 3853530, Regulating plants with n-phosphonomethylglycine and derivatives thereof * Patent Number: 3977860, Herbicidal compositions and methods employing esters of * Patent Number: 3954848, Process for producing N-phosphonomethy glycine * Patent Number: 4735649, Gametocides * Patent Number: 4634788, Herbicidal glyphosate oxime derivatives * Patent Number: 4094661, Plant Growth RegulatorsUS4094661
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External links

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References

{{DEFAULTSORT:Franz, John E. 1929 births Living people 21st-century American chemists Organic chemists National Medal of Technology recipients University of Illinois alumni University of Minnesota alumni Monsanto Chemists from Missouri