JWH-359 is a

dibenzopyran Xanthene (9''H''-xanthene, 10''H''-9-oxaanthracene) is the organic compound with the formula CH2 6H4sub>2O. It is a yellow solid that is soluble in common organic solvents. Xanthene itself is an obscure compound, but many of its derivatives are us ...

"classical" cannabinoid drug, which is a potent and selective CB₂ receptor agonist, with a K_i of 13.0 nM and selectivity of around 220 times for CB₂ over CB₁ receptors. It is related to other dibenzopyran CB₂ agonists such as JWH-133 and

L-759,656 L-759,656 is an analgesic drug that is a cannabinoid agonist. It is a highly selective agonist for the CB2 receptor, with selectivity of 414x for CB2 over CB1, although it is still not as selective as newer agents such as HU-308. It produces ...

but with a

chiral Chirality is a property of asymmetry important in several branches of science. The word ''chirality'' is derived from the Greek (''kheir''), "hand", a familiar chiral object. An object or a system is ''chiral'' if it is distinguishable from ...

side chain which has made it useful for mapping the shape of the CB₂ binding site. It was discovered by, and named after,

John W. Huffman John William Huffman (1932–2022) was a professor of organic chemistry at Clemson University who first synthesised novel cannabinoids. His research, funded by the National Institute on Drug Abuse, was focused on making a drug to target endocanna ...

References

JWH cannabinoids Benzochromenes Phenol ethers Methoxy compounds {{cannabinoid-stub