JWH-302 (1-pentyl-3-(3-methoxyphenylacetyl)indole) is an

analgesic An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...

chemical from the phenylacetylindole family, which acts as a

cannabinoid Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tet ...

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ag ...

with moderate affinity at both the CB₁ and CB₂ receptors. It is a

positional isomer In chemistry, a structural isomer (or constitutional isomer in the IUPAC nomenclature) of a compound is another compound whose molecule has the same number of atoms of each element, but with logically distinct bonds between them. The term meta ...

of the more common drug JWH-250, though it is slightly less potent with a ''K''_i of 17 nM at CB₁, compared to 11 nM for JWH-250. Because of their identical

molecular weight A molecule is a group of two or more atoms held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions which satisfy this criterion. In quantum physics, organic chemistry, and bio ...

and similar fragmentation patterns, JWH-302 and JWH-250 can be very difficult to distinguish by GC-MS testing. In the United States, CB₁ receptor agonists of the 3-phenylacetylindole class such as JWH-302 are

Schedule I Controlled Substance This is the list of Schedule I drugs as defined by the United States Controlled Substances Act. 21 CFRbr>1308.11(CSA Sched I) with changes through (Oct 18, 2012). Retrieved September 6, 2013. The following findings are required for drugs to be pla ...

References

JWH cannabinoids Phenylacetylindoles Phenol ethers CB1 receptor agonists CB2 receptor agonists {{Cannabinoid-stub