JWH-148 is a synthetic cannabimimetic that was discovered by
John W. Huffman
John William Huffman (1932–2022) was a professor of organic chemistry at Clemson University who first synthesised novel cannabinoids. His research, funded by the National Institute on Drug Abuse, was focused on making a drug to target endocanna ...
. It is the indole 2-methyl analog of
JWH-120. It is a moderately selective ligand for the
CB2 receptor, with a binding affinity of ''K''
i = 14.0 ± 1.0 nM at this subtype, and more than eight times selectivity over the CB
1 subtype.
In the United States, all CB
1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-148 are
Schedule I Controlled Substance
This is the list of Schedule I drugs as defined by the United States Controlled Substances Act. 21 CFRbr>1308.11(CSA Sched I) with changes through (Oct 18, 2012). Retrieved September 6, 2013. The following findings are required for drugs to be pl ...
s.
See also
*
JWH-120
*
JWH-122
JWH-122 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is a methylated analogue of JWH-018. It has a Ki of 0.69 nM at CB1 and 1.2 nM at CB2.
In January 2015, over 40 people were reportedly sickened after eating a holid ...
*
JWH-193
JWH-193 is a drug from the aminoalkylindole and naphthoylindole families which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-193 has a binding affinity at the CB1 r ...
*
JWH-210
JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. It is one of the most potent 4-substi ...
*
JWH-398
JWH-398 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It has mild selectivity for CB1 with a Ki of 2.3 nM and 2.8 nM at CB2. This synthetic chemical comp ...
References
{{cannabinoid-stub
JWH cannabinoids
Naphthoylindoles
CB1 receptor agonists
CB2 receptor agonists