JWH-122 is a synthetic cannabimimetic that was discovered by
John W. Huffman
John William Huffman (1932–2022) was a professor of organic chemistry at Clemson University who first synthesised novel cannabinoids. His research, funded by the National Institute on Drug Abuse, was focused on making a drug to target endocanna ...
. It is a methylated analogue of
JWH-018
JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO or AM-678) is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in ...
. It has a
Ki of 0.69 nM at CB
1 and 1.2 nM at CB
2.
In January 2015, over 40 people were reportedly sickened after eating a holiday bread called
Rosca de reyes
A king cake, also known as a three kings cake, is a cake associated in many countries with Epiphany. Its form and ingredients are variable, but in most cases a () such as a figurine, often said to represent the Christ Child, is hidden inside. ...
purchased at a bakery in Santa Ana, CA that was laced with JWH-122.
Legal status
Australia
JWH-122 is considered a Schedule 9 prohibited substance in Australia under the
Poisons Standard (October 2015).
A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.
China
As of October 2015 JWH-122 is a controlled substance in China.
United States
In the United States, JWH-122 is a
Schedule I Controlled Substance
This is the list of Schedule I drugs as defined by the United States Controlled Substances Act. 21 CFRbr>1308.11(CSA Sched I) with changes through (Oct 18, 2012). Retrieved September 6, 2013. The following findings are required for drugs to be pl ...
.
See also
*
JWH-193
JWH-193 is a drug from the aminoalkylindole and naphthoylindole families which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-193 has a binding affinity at the CB1 r ...
*
JWH-210
JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. It is one of the most potent 4-substi ...
*
JWH-398
JWH-398 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It has mild selectivity for CB1 with a Ki of 2.3 nM and 2.8 nM at CB2. This synthetic chemical comp ...
*
List of JWH cannabinoids
The John W. Huffman research group at Clemson University synthesized over 450 cannabinoids. Some of those are: