Iroquois homeobox factors are a family of homeodomain transcription factors that play a role in many developmental processes.[1][2] The loci were named for the flies carrying mutations in one of these genes, which are devoid of all bristles in the lateral part of the notum, leaving only a median stripe of bristles, similar to the Iroquois tribes which shaved all but a medial stripe of hairs on the head.[3]

Human genes that encode Iroquois homeobox factors include:[2]


  1. ^ Gómez-Skarmeta JL, Modolell J (August 2002). "Iroquois genes: genomic organization and function in vertebrate neural development". Curr. Opin. Genet. Dev. 12 (4): 403–8. doi:10.1016/S0959-437X(02)00317-9. PMID 12100884. 
  2. ^ a b Kerner P, Ikmi A, Coen D, Vervoort M (2009). "Evolutionary history of the iroquois/Irx genes in metazoans". BMC Evol. Biol. 9: 74. doi:10.1186/1471-2148-9-74. PMC 2674049Freely accessible. PMID 19368711. 
  3. ^ Leyns L, Gómez-Skarmeta JL, Dambly-Chaudière C (September 1996). "iroquois: a prepattern gene that controls the formation of bristles on the thorax ofDrosophila". Mech. of Dev. 59 (1): 63–72. PMID 8892233.