History
In 1929, Dr. Henri Beaufour founded the Beaufour Laboratories in Dreux. The first product marketed was Romarene, a rosemary-based medicine intended for the treatment of digestive disorders, discontinued from the market in 2011. In the 1950s and 1960s, Laboratoires Beaufour underwent a phase of expansion. In 1954, the group launched betaine citrate, used in the symptomatic treatment of dyspepsia. Henri Beaufour's two sons, Albert and Gérard Beaufour, joined the company. The group opened a factory in Dreux in 1961, and another in L'Isle- sur-la-Sorgue in 1965. A research center opened in Plessis-Robinson the same year. In the 1970s and 1980s, Laboratoires Beaufour created a subsidiary, Ipsen (1975), and began to internationalize its activities. In 1976, the company opened a research center in Milford (Massachusetts) in the U.S. In 1977, the group launched Smecta (diosmectite clay, a gastrointestinal bandage and anti-diarrhoeal agent). In 1983, the group created the Fondation Ipsen under the aegis of the Fondation de France, to encourage exchanges between scientists in the field of life sciences. In 1986, the group launched Decapeptyl, used to treat certain pathologies influenced by sex hormones, such as prostate cancer, endometriosis, uterine fibroids and early puberty. In the 1990s, the group diversified its activity and continued its international expansion. In 1990, an industrial center was created in Signes, in the Var department. In 1992, the group opened a subsidiary in China. In 1994, the group launched Dysport (type A botulinum toxin for the treatment of muscle spasms) after acquiring the British company Speywood (then called Porton International). The same year, the group opened a subsidiary in Russia. In 1995, the group launched Somatuline, used to treat hypersecretion of growth hormones (acromegaly) and in neuro-endocrine tumors, and in 1996, Forlax was launched. In 2000, the death of Albert Beaufour, son of the founder and majority shareholder of the group, triggered "a long and quiet battle", notes Forbes magazine, for the management of the group. It was finally won by the grandchildren, Anne Beaufour and Henri Beaufour, who used trusts registered in the tax haven of Bermuda to organize their succession. In 2003, the company changed its name to Ipsen and in 2005, it was listed on the Paris Stock Exchange on Euronext. In 2004, the company inaugurated a new botulinum toxin production unit in Wrexham (UK). In 2007, the company established a partnership with Galderma for botulinum toxin type A products in aesthetic medicine. In addition, somatuline was granted marketing authorization in the United States for the treatment of acromegaly. In 2007, Ipsen shares were included in the SBF 120 stock market index. In 2007, Dysport was granted marketing authorization in the United States for certain indications in therapeutic and aesthetic medicine. Decapeptyl 6-month formulation receives marketing authorization in 9 European countries from the European Medicines Agency. In 2011, Ipsen announced a new strategy focusing on several areas, including a refocus on specialty medicine, research and development and international development. In 2013, Ipsen acquired the British company Syntaxin, a leader in the engineering of recombinant botulinum toxin11. In 2014, the company participated in the creation of a joint laboratory with the CNRS - Archi-Pex -, the ''Commissariat à l'énergie atomique et aux énergies alternatives'' and the University of Rennes1, with the aim of designing and developing hormone peptides. In 2015, Ipsen inaugurated a research and development center in Cambridge, Massachusetts. In 2016, Dysport Injection was approved in the United States for the treatment of lower limb spasticity in children aged two years and older. In 2016, Ipsen licensed cabozantinib from Exelixis, which received marketing authorization the same year for the second-line treatment of advanced renal cell carcinoma. In January 2017, Ipsen announced the acquisition of certain assets of Merrimack Pharmaceuticals, including Onivyde, for the treatment of pancreatic and ovarian cancer. In 2019, Ipsen acquired Montreal-based Clementia Pharmaceuticals, specializing in rare bone diseases,, ,. Clementia brought a drug candidate, palovarotene, to Ipsen for a rare genetic disease, fibrodysplasia ossificans progressiva (FOP). In February 2022, Ipsen announced the proposed sale of the Consumer HealthCare (CHC) division after entering into exclusive negotiations with the French laboratory Mayoly Spindler. In July 2022, Ipsen completed the divestment of the CHC business to Mayoly Spindler. In August 2022, Ipsen successfully completed the acquisition of Epizyme and its lead medicine, Tazverik® (tazemetostat), a first-in-class, chemotherapy-free EZH2a inhibitor for adults with relapsed or refractory follicular lymphoma (FL), which was granted Accelerated Approval by the U.S. Food and Drug Administration (FDA) in 2020. As part of the transaction, Ipsen also acquired Epizyme’s first-in-class, oral SETD2 inhibitor development candidate.Financial Data
Shareholding
Ownership of Ipsen’s share capital (% of total capital) as of 31 December 2021:Medicines
In Oncology
Cabometyx (''cabozantinib'') is a tyrosine kinase inhibitor (TKI) used in the treatment of advanced kidney cancer (renal cell carcinoma), liver cancer (hepatocellular carcinoma) in adults previously treated with the medicine sorafenib, as well as in radioiodine-refractory differentiated thyroid cancer (RAI-R DTC) after prior systemic therapy Decapeptyl (''triptorelin'') is an analogue of the natural gonadotropin-releasing hormone (GnRH), approved for the treatment of locally advanced metastatic prostate cancer, central precocious puberty (CPP) endometriosis, uterine fibroma, and in-vitro fertilization, and used as adjuvant treatment in combination with tamoxifen or an aromatase inhibitor for women at high-risk of breast cancer recurrence. Somatuline ''(lanreotide'') is a synthetic (analogue) version of the natural hormone somatostatin, which is found naturally in the human body. Used for the treatment of neuroendocrine tumors (NETs), carcinoid syndrome or acromegaly. Onivyde (''irinotecan liposome injection'') is prescribed in combination with fluorouracil (5-FU) and leucovorin (LV), for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. Tazverik (t''azemetosta''t) is a methyl transferase inhibitor of EZH2 (enhancer of zeste homologue 2) used to treat people living follicular lymphoma, which is a cancer of the lymphatic system, as well as epithelioid sarcoma which is a rare, slow-growing type of soft tissue cancer which often begin in the soft tissue under the skin of a finger, hand, forearm, lower leg or foot, and in the abdomen or pelvic area. These indications are approved under FDA accelerated approval based on overall response rate and duration of response. Continued approval for these indications may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).In Rare Disease
Increlex (mecasermin) injection is a prescription medicine used to treat children who are very short for their age because their bodies do not make enough IGF-1. This condition is called primary IGF-1 deficiency. Sohonos (''palovarotene'') is an oral investigational, selective retinoic-acid receptor gamma (RARγ) agonist being developed as a potential treatment for people living with the debilitating ultra-rare genetic disorder fibrodysplasia ossificans progressiva (FOP).In Neuroscience
Dysport (''Botulinum toxin'') is a prescription medicine used for pathologies characterized by involuntary and uncomfortable muscle contractions (dystonias: blepharospasm, spasmodic torticollis, hemifacial spasm; spasticity: spasticity of the upper or lower limb, dynamic deformation of the equine foot). This drug is also used in aesthetic medicine to temporarily reduce certain wrinkles.Fondation Ipsen
The ''Fondation Ipsen pour la recherche thérapeutique'', created in 1983 under the aegis of the ''Fondation de France'', supports work in the field of therapeutic research32. In particular is focused on helping improve the lives of patients with rare diseases. It has contributed to numerous major advances in biological and medical research, organized scientific conferences, and produced literature and content to help patients and the wider community understand rare diseases. Since 2007, Fondation Ipsen has initiated several series of meetings in partnership with the Salk Institute, the Karolinska Institutet, the Massachusetts General Hospital, the DMMGF (Days of Molecular Medicine Global Foundation), as well as with the journals Nature, Cell and Science. The Fondation Ipsen has published more than 100 books and awarded more than 250 prizes and grants. In 2021, Fondation Ipsen worked directly with 146 organizations to assess the needs of patients with rare diseases. Fondation Ipsen and ''Science Magazine'' organized 9 webinars with the world’s leading specialists in rare diseases, as well as policymakers from all over the world.The webinars addressed a variety of essential topics for patients living with rare diseases and their families. The webinars received such a strong response that Science Magazine and the Fondation now co-publish an international magazine for the rare disease community: ''The Rare Disease Gazette''.References
External links
* {{Authority control Pharmaceutical companies established in 1929 Pharmaceutical companies of France French companies established in 1929 Manufacturing companies based in Paris Companies listed on Euronext Paris