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The International System for Human Cytogenomic Nomenclature (previously International System for Human Cytogenetic Nomenclature), ISCN in short, is an international standard for 
Abbreviations of this system include a minus sign (-) for chromosome deletions, and ''del'' for deletions of parts of a chromosome.
"Standardization in Human Cytogenetics." (PDF)
''Birth Defects: Original Article Series'', Vol 8, No 7 (The National Foundation, New York 1972) * Chicago Conference (1966): "Standardization in Human Cytogenetics." ''Birth Defects: Original Article Series'', Vol 2, No 2 (The National Foundation, New York 1966). * London Conference (1963)
"London Conference on the Normal Human Karyotype."
''Cytogenetics'' 2:264–268 (1963) * Denver Conference (1960)
"A proposed standard system of nomenclature of human mitotic chromosomes."
''The Lancet'' 275.7133 (1960): 1063-1065.
About the ISCN recommendations
- Human Genome Variation Society {{Chromosome genetics Cytogenetics Biological nomenclature
human chromosome
A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins are ...
nomenclature
Nomenclature (, ) is a system of names or terms, or the rules for forming these terms in a particular field of arts or sciences. The principles of naming vary from the relatively informal naming conventions, conventions of everyday speech to the i ...
, which includes band names, symbols and abbreviated terms used in the description of human chromosome and chromosome abnormalities
A chromosomal abnormality, chromosomal anomaly, chromosomal aberration, chromosomal mutation, or chromosomal disorder, is a missing, extra, or irregular portion of chromosomal DNA. These can occur in the form of numerical abnormalities, where ther ...
.
The ISCN has been used as the central reference among cytogeneticist
Cytogenetics is essentially a branch of genetics, but is also a part of cell biology/cytology (a subdivision of human anatomy), that is concerned with how the chromosomes relate to cell behaviour, particularly to their behaviour during mitosis a ...
s since 1960.Slovak M.L., Theisen A., Shaffer L.G. (2013) "Human Chromosome Nomenclature: An Overview and Definition of Terms." In: Gersen S., Keagle M. (eds) ''The Principles of Clinical Cytogenetics.'' Springer, New York, NY
Abbreviations of this system include a minus sign (-) for chromosome deletions, and ''del'' for deletions of parts of a chromosome.
Revision history
* ISCN (2020). S. Karger Publishing. * ISCN (2016). S. Karger Publishing. * ISCN (2013). S. Karger Publishing. * ISCN (2009). S. Karger Publishing. * ISCN (2005). S. Karger Publishing. * ISCN (1995). S. Karger Publishing. * ISCN (1991). S. Karger Publishing. * ISCN (1985). S. Karger Publishing. * ISCN (1981). S. Karger Publishing. * ISCN (1978). S. Karger Publishing. * Paris Conference (1971)"Standardization in Human Cytogenetics." (PDF)
''Birth Defects: Original Article Series'', Vol 8, No 7 (The National Foundation, New York 1972) * Chicago Conference (1966): "Standardization in Human Cytogenetics." ''Birth Defects: Original Article Series'', Vol 2, No 2 (The National Foundation, New York 1966). * London Conference (1963)
"London Conference on the Normal Human Karyotype."
''Cytogenetics'' 2:264–268 (1963) * Denver Conference (1960)
"A proposed standard system of nomenclature of human mitotic chromosomes."
''The Lancet'' 275.7133 (1960): 1063-1065.
See also
*Locus (genetics)
In genetics, a locus (plural loci) is a specific, fixed position on a chromosome where a particular gene or genetic marker is located. Each chromosome carries many genes, with each gene occupying a different position or locus; in humans, the total ...
* Cytogenetic notation
The following table summarizes symbols and abbreviations used in cytogenetics:
See also
* Chromosome abnormalities
*Directionality (molecular biology) for 3' and 5' notation
*locus (genetics) for basic notational system
*International System for ...
References
External links
About the ISCN recommendations
- Human Genome Variation Society {{Chromosome genetics Cytogenetics Biological nomenclature