Internal control region
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An internal control region is a sequence of DNA located with the
coding region The coding region of a gene, also known as the coding sequence (CDS), is the portion of a gene's DNA or RNA that codes for protein. Studying the length, composition, regulation, splicing, structures, and functions of coding regions compared to no ...
of
eukaryotic Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bacte ...
genes In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
that binds regulatory elements such as activators or
repressors In molecular genetics, a repressor is a DNA-binding protein, DNA- or RNA-binding protein that inhibits the Gene expression, expression of one or more genes by binding to the Operator (biology), operator or associated Silencer (DNA), silencers. ...
. This region can recruit
RNA Polymerase In molecular biology, RNA polymerase (abbreviated RNAP or RNApol), or more specifically DNA-directed/dependent RNA polymerase (DdRP), is an enzyme that synthesizes RNA from a DNA template. Using the enzyme helicase, RNAP locally opens the ...
or contribute to splicing.


See also

* DNA *
Gene expression Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. The ...
*
Gene family A gene family is a set of several similar genes, formed by duplication of a single original gene, and generally with similar biochemical functions. One such family are the genes for human hemoglobin subunits; the ten genes are in two clusters on ...


References

*{{cite book , first = Richard , last = Dawkins , authorlink = Richard Dawkins , title = The Selfish Gene , publisher = Oxford University Press , year = 1990 , isbn = 978-0-19-286092-7 , title-link = The Selfish Gene }
Google Book Search
first published 1976. * * *


External links


DNA From The Beginning - a primer on genes and DNA

Genes And DNA - Introduction to genes and DNA aimed at non-biologist

ENCODE threads Explorer
Characterization of intergenic regions and gene definition.
Nature (journal) ''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features peer-reviewed research from a variety of academic disciplines, mainly in science and technology. ...
* Molecular biology