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NM_001546

NM_031166

RefSeq (protein)

NP_001537

NP_112443

Location (UCSC) Chr 6: 19.84 – 19.84 Mb Chr 13: 48.26 – 48.27 Mb PubMed search [3] [4] Wikidata
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DNA-binding protein inhibitor ID-4 is a protein that in humans is encoded by the ID4 gene.[5][6]

Function

Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative (antimorph) HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172201 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021379 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Pagliuca A, Bartoli PC, Saccone S, Della Valle G, Lania L (Oct 1995). "Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22". Genomics. 27 (1): 200–3. doi:10.1006/geno.1995.1026. PMID 7665172. 
  6. ^ a b "Entrez Gene: ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein". 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.