ICI-204,448 is a drug which acts as a potent and peripherally selective κ-opioid agonist, with possible uses in the treatment of

heart attack A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to the coronary artery of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which ma ...

as well as anti-

itching Itch (also known as pruritus) is a Wikt:sensation, sensation that causes the desire or reflex to scratch. Itch has resisted many attempts to be classified as any one type of Sensory system, sensory experience. Itch has many similarities to pain, ...

effects. It is used in research to distinguish centrally from peripherally mediated kappa opioid receptor effects.

References

Synthetic opioids Chloroarenes Acetamides Pyrrolidines Kappa-opioid receptor agonists Phenol ethers Acetic acids Peripherally selective drugs {{analgesic-stub