Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a
protein that in humans is encoded by the ''HCN1''
gene.
Function
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.
Tissue distribution
HCN1 channel expression is found in the sinoatrial node,
the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.
Interactions
HCN1 has been shown to
interact
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with
HCN2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the ''HCN2'' gene.
Interactions
HCN2 has been shown to interact with HCN1 and HCN4.
Function
The function of the ...
.
Epilepsy
De novo mutations in HCN1 cause
epilepsy.
See also
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Cyclic nucleotide-gated ion channel
References
Further reading
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External links
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Ion channels
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