Hussein Arab Isse (Somali: Xuseen Carab Ciise, Arabic: حسين عرب عيسى), also spelled Hussein Arab Issa, is a Somali politician. He was the Minister of Defence and the Deputy Prime Minister of Somalia from 20 July 2011 to 4 November 2012.
On 18 October 2011, Isse and other Transitional Federal Government (TFG) officials hosted a Kenyan delegation in Mogadishu to discuss security issues cooperation against Al-Shabaab as part of the ongoing coordinated Operation Linda Nchi. Isse and Kenya's Minister of Defence Mohamed Yusuf Haji then signed an agreement to collaborate against the insurgent group. In early June 2012, Kenyan forces were formally integrated into AMISOM.
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