Holdase
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In
molecular biology Molecular biology is the branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, molecular synthesis, modification, mechanisms, and interactions ...
, holdases are a particular kind of
molecular chaperones Chaperone proteins participate in the folding of over half of all mammalian proteins. In molecular biology, molecular chaperones are protein Proteins are large biomolecules or macromolecules that are comprised of one or more long chains of amin ...
that assist the non-covalent folding of proteins in an ATP-independent manner. Examples of holdases are
DnaJ In molecular biology, chaperone DnaJ, also known as Hsp40 (heat shock proteinHeat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to ...
and
Hsp33 Hsp33 protein is a molecular chaperone Chaperone proteins participate in the folding of over half of all mammalian proteins. In molecular biology, molecular chaperones are proteins that assist the conformational folding or unfolding and the assemb ...
. Holdases bind to protein folding intermediates to prevent their aggregation but without directly refolding them.


References

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See also

* Foldase * Chaperonin * Co-chaperone Molecular chaperones Protein biosynthesis