It was briefly divided into Hesse-Homburg and Hesse-Homburg-Bingenheim; but these parts were reunited in 1681.
In 1806, Hesse-Homburg was incorporated with Hesse-Darmstadt; but in 1815, by the Congress of Vienna, the latter state was compelled to recognize the independence of Hesse-Homburg, which was increased by the addition of Meisenheim.
In 1866, Hesse-Homburg was inherited by the grand-duke of Hesse-Darmstadt, while Meisenheim fell to Prussia. Later that same year, these territories were taken from Hesse-Darmstadt again, and the former landgraviate was combined with the Electorate of Hesse-Kassel, duchy of Nassau, and the free city of Frankfurt to form the Prussian province of Hesse-Nassau.
Today, it forms a part of the German state of Hesse.