Hemogenic endothelium is a special subset of endothelial cells scattered within blood vessels that can differentiate into
haematopoietic
Haematopoiesis (, from Greek , 'blood' and 'to make'; also hematopoiesis in American English; sometimes also h(a)emopoiesis) is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells. ...
cells.
The development of hematopoietic cells in the embryo proceeds sequentially from
mesoderm through the
hemangioblast
Hemangioblasts are the multipotent precursor cells that can differentiate into both hematopoietic and endothelial cells. In the mouse embryo, the emergence of blood islands in the yolk sac at embryonic day 7 marks the onset of hematopoiesis. From ...
to the hemogenic endothelium and hematopoietic progenitors.
[C. Lancrin, P. Sroczynska, C. Stephenson, et al. The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature 2009;457:892–895]
See also
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Hemangioblast
Hemangioblasts are the multipotent precursor cells that can differentiate into both hematopoietic and endothelial cells. In the mouse embryo, the emergence of blood islands in the yolk sac at embryonic day 7 marks the onset of hematopoiesis. From ...
References
Cell biology
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