RefSeq (protein)



Location (UCSC) Chr 6: 122.4 – 122.43 Mb Chr 10: 57.49 – 57.51 Mb PubMed search [3] [4] Wikidata
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Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.[5][6]


HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.[6]


HSF2 has been shown to interact with Nucleoporin 62[7] and HSF1.[8]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000025156 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019878 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE (Sep 1991). "Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans". Proc Natl Acad Sci U S A. 88 (16): 6911–5. doi:10.1073/pnas.88.16.6911. PMC 52203Freely accessible. PMID 1871106. 
  6. ^ a b "Entrez Gene: HSF2 heat shock transcription factor 2". 
  7. ^ Yoshima T, Yura T, Yanagi H (Nov 1997). "The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62". Biochem. Biophys. Res. Commun. 240 (1): 228–33. doi:10.1006/bbrc.1997.7662. PMID 9367915. 
  8. ^ He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK (Sep 2003). "Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress". J. Biol. Chem. 278 (37): 35465–75. doi:10.1074/jbc.M304663200. PMID 12813038. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.