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HPR may refer to: * Handley Page (Reading) * Haptoglobin-related protein, a protein and gene in humans * ''Harvard Political Review'' * Hawaii Public Radio * Heading, pitch, roll; see flight dynamics * Heartland Public Radio * Heparanase * High-power rocketry * Highly Protected Risk (insurance terminology); see FM Global * Holding period return * IBM Home Page Reader, a self-voicing web browser for blind users * ''Homiletic and Pastoral Review'' * Hornsdale Power Reserve, a utility-scale battery in South Australia * Host plant resistance * Human Proteome Resource program * Hungarian People's Republic * Hunt, point, and retrieve, categories of dog breeds; see pointing breed * Hydroacoustic Position Reference * Honza PRůša (painter, writer and actor from Czech Republic) {{disambiguation