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NM_019558
NM_001199746
NM_001199747

NM_001290730
NM_001290731
NM_008276

RefSeq (protein)

NP_001186675
NP_001186676
NP_062458

NP_001277659
NP_001277660
NP_032302

Location (UCSC) Chr 2: 176.13 – 176.13 Mb Chr 2: 74.7 – 74.71 Mb PubMed search [3] [4] Wikidata
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Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.[5][6][7]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175879 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027102 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  6. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  7. ^ a b "Entrez Gene: HOXD8 homeobox D8". 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.